ArticleBMC genetics2007
Patterns of population differentiation of candidate genes for cardiovascular disease.
Article in BMC genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
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- Molecular cloning and characterization of NPR1 gene from Arachis hypogaea.Molecular biology reports · 2014Article
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- Screen for Footprints of Selection during Domestication/Captive Breeding of Atlantic Salmon.Comparative and functional genomics · 2012Article
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- A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS.BMC genomics · 2011Article
- Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease.BMC medical genetics · 2011Article
- What happened after the initial global spread of pandemic human influenza virus A (H1N1)? A population genetics approach.Virology journal · 2010Article
- Genetic variants associated with complex human diseases show wide variation across multiple populations.Public health genomics · 2010Article
- Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites.BMC genetics · 2009Article
- Molecular population genetics of PCSK9: a signature of recent positive selection.Pharmacogenetics and genomics · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe basis for ethnic differences in cardiovascular disease (CVD) susceptibility is not fully understood. We investigated patterns of population differentiation (FST) of a set of genes in etiologic pathways of CVD among 3 ethnic groups: Yoruba in Nigeria (YRI), Utah residents with European ancestry (CEU), and Han Chinese (CHB) + Japanese (JPT). We identified 37 pathways implicated in CVD based on the PANTHER classification and 416 genes in these pathways were further studied; these genes belonged to 6 biological processes (apoptosis, blood circulation and gas exchange, blood clotting, homeostasis, immune response, and lipoprotein metabolism). Genotype data were obtained from the HapMap database.
resultsWe calculated FST for 15,559 common SNPs (minor allele frequency > or = 0.10 in at least one population) in genes that co-segregated among the populations, as well as an average-weighted FST for each gene. SNPs were classified as putatively functional (non-synonymous and untranslated regions) or non-functional (intronic and synonymous sites). Mean FST values for common putatively functional variants were significantly higher than FST values for nonfunctional variants. A significant variation in FST was also seen based on biological processes; the processes of 'apoptosis' and 'lipoprotein metabolism' showed an excess of genes with high FST. Thus, putative functional SNPs in genes in etiologic pathways for CVD show greater population differentiation than non-functional SNPs and a significant variance of FST values was noted among pairwise population comparisons for different biological processes.
conclusionThese results suggest a possible basis for varying susceptibility to CVD among ethnic groups.
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