ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Chronic mild stress during gestation worsens neonatal brain lesions in mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 62 citations in OpenAlex.
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- Corticotropin-Releasing Factor Receptor 1 in the Anterior Cingulate Cortex Mediates Maternal Absence-Induced Attenuation of Transport Response in Mouse Pups.Frontiers in cellular neuroscience · 2018Article
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- What are the Best Animal Models for Testing Early Intervention in Cerebral Palsy?Frontiers in neurology · 2014Review
- A 24-hour dietary recall for assessing the intake pattern of choline among Bangladeshi pregnant women at their third trimester of pregnancy.Central Asian journal of global health · 2014Article
- Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation.Cell death and differentiation · 2013Article
- Effect of Restraint Stress during Gestation on Pentylenetetrazol-Induced Epileptic Behaviors in Rat Offspring.Iranian journal of basic medical sciences · 2013Article
- Anatomic, hematologic, and biochemical features of C57BL/6NCrl mice maintained on chronic oral corticosterone.Comparative medicine · 2012Article
- Neonatal intensive care unit stress is associated with brain development in preterm infants.Annals of neurology · 2011Article
- Pitfalls in the quest of neuroprotectants for the perinatal brain.Developmental neuroscience · 2011Article
- Normal maternal behavior, but increased pup mortality, in conditional oxytocin receptor knockout females.Behavioral neuroscience · 2010Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral palsy remains a public health priority. Recognition of factors of susceptibility to perinatal brain lesions is key for the prevention of cerebral palsy. In most cases, the pathophysiology of these lesions is thought to involve prior exposure to predisposing factors that make the developing brain more vulnerable to perinatal events. The present study tested the hypothesis that exposure to chronic minimal stress throughout gestation would sensitize the offspring to neonatal excitotoxic brain lesions, which mimic lesions observed in cerebral palsy. Pregnant mice were exposed to chronic, ultramild stress, applied throughout gestation. Neonatal brain lesions were induced by intracerebral injection of glutamate analogs. Excitotoxic lesions were significantly worsened in pups exposed to gestational stress. Stress induced a significant rise of circulating corticosterone levels both in pregnant mothers and in newborn pups. The deleterious effects of stress on excitotoxicity were totally suppressed in mice with reduced levels of glucocorticoid receptors. Stress induced a significant increase of neopallial NMDA binding sites in the offspring. At adulthood, animals exposed to stress and neonatal excitotoxic challenge showed a significant impairment in the Morris water maze test when compared with animals exposed to the excitotoxic challenge but not the gestational stress. These findings suggest that stress during gestation, which may mimic low-level stress in human pregnancy, could be a novel risk factor for cerebral palsy.
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