ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Altered localization of GABA(A) receptor subunits on dentate granule cell dendrites influences tonic and phasic inhibition in a mouse model of epilepsy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.
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Who cites it
108 citing papers in PubMed, 222 citations in OpenAlex.
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- WONOEP XVII appraisal: Targeting network excitability beyond the synapse -Neurotransmitter, ionic, and electro -diffusions.Epilepsia · 2025Review
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- The effect of traumatic brain injury on learning and memory: A synaptic focus.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- In the fast lane: Receptor trafficking during status epilepticus.Epilepsia open · 2023Review
- The fate of interneurons, GABABrain pathology (Zurich, Switzerland) · 2023Review
- Virally-induced expression of GABAProgress in neurobiology · 2022Article
- Increased Voluntary Alcohol Consumption in Mice Lacking GABAFrontiers in behavioral neuroscience · 2022Article
- Zolpidem Profoundly Augments Spared Tonic GABAFrontiers in systems neuroscience · 2022Article
- Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy.Frontiers in synaptic neuroscience · 2022Review
- Sleep Deprivation Exacerbates Seizures and Diminishes GABAergic Tonic Inhibition.Annals of neurology · 2021Article
- Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.Cell reports · 2021Article
- Progesterone modulates neuronal excitability bidirectionally.Neuroscience letters · 2021Review
- Increased expression of GABABrain communications · 2021Article
- Immunohistochemical distribution of 10 GABAThe Journal of comparative neurology · 2020Article
- Review
- Silencing of spontaneous activity at α4β1/3δ GABABritish journal of pharmacology · 2020Article
- Reduced neurosteroid potentiation of GABAAnnals of clinical and translational neurology · 2020Article
48 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Complex changes in GABA(A) receptors (GABA(A)Rs) in animal models of temporal lobe epilepsy during the chronic period include a decrease in the delta subunit and increases in the alpha4 and gamma2 subunits in the dentate gyrus. We used postembedding immunogold labeling to determine whether the subcellular locations of these subunits were also altered in pilocarpine-treated epileptic mice, and related functional changes were identified electrophysiologically. The ultrastructural studies confirmed a decrease in delta subunit labeling at perisynaptic locations in the molecular layer of the dentate gyrus where these subunits are critical for tonic inhibition. Unexpectedly, tonic inhibition in dentate granule cells was maintained in the epileptic mice, suggesting compensation by other GABA(A)Rs. An insensitivity of the tonic current to the neurosteroid tetrahydrodeoxy-corticosterone was consistent with decreased expression of the delta subunit. In the pilocarpine-treated mice, alpha4 subunit labeling remained at perisynaptic locations, but increased gamma2 subunit labeling was also found at many perisynaptic locations on granule cell dendrites, consistent with a shift of the gamma2 subunit from synaptic to perisynaptic locations and potential partnership of the alpha4 and gamma2 subunits in the epileptic animals. The decreased gamma2 labeling near the center of synaptic contacts was paralleled by a corresponding decrease in the dendritic phasic inhibition of granule cells in the pilocarpine-treated mice. These GABA(A)R subunit changes appear to impair both tonic and phasic inhibition, particularly at granule cell dendrites, and could reduce the adaptive responses of the GABA system in temporal lobe epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.