ArticleJournal of clinical microbiology2007
Deletion of the meningococcal fetA gene used for antigen sequence typing of invasive and commensal isolates from Germany: frequencies and mechanisms.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Pharyngeal carriage of Neisseria species in the African meningitis belt.The Journal of infection · 2016Trial
- Bacterial genome instability.Microbiology and molecular biology reviews : MMBR · 2014Review
- Genetic distribution of noncapsular meningococcal group B vaccine antigens in Neisseria lactamica.Clinical and vaccine immunology : CVI · 2013Article
- Article
- Clonal analysis of Neisseria meningitidis serogroup B strains in South Africa, 2002 to 2006: emergence of new clone ST-4240/6688.Journal of clinical microbiology · 2012Article
- Characterization of Neisseria meningitidis isolates that do not express the virulence factor and vaccine antigen factor H binding protein.Clinical and vaccine immunology : CVI · 2011Article
- Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005.The Journal of infectious diseases · 2010Article
- Comparative analysis of two Neisseria gonorrhoeae genome sequences reveals evidence of mobilization of Correia Repeat Enclosed Elements and their role in regulation.BMC genomics · 2009Article
- A common gene pool for the Neisseria FetA antigen.International journal of medical microbiology : IJMM · 2009Article
- Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Antigen sequence typing (ST) of FetA is part of the molecular typing scheme of Neisseria meningitidis. Among invasive meningococcal isolates from 2,201 patients in Germany, we identified 11 strains lacking the fetA gene because of deletions mediated by repeat arrays flanking the gene, i.e., Correia elements, repeat sequence 13 (RS13), and duplicated RS3. Geographic mapping and multilocus ST of invasive isolates revealed that fetA deletion was a sporadic event without genetic fixation. Among 821 carrier strains, 12 strains lacked fetA, suggesting that fetA is maintained during asymptomatic carriage. Interestingly, most of these isolates belonged to the multilocus ST-35 clonal complex (cc). ST-35 cc strains and the recently published ST-192 strains from Burkina Faso may benefit from loss of fetA, but their infrequent occurrence among invasive isolates currently does not affect fetA antigen ST.
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