ArticleDevelopment (Cambridge, England)2007
Regulation of the Arabidopsis root vascular initial population by LONESOME HIGHWAY.
Article in Development (Cambridge, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- Involvement of tRNA thiolation in uORF-mediated translational regulation during Xylogenesis in Arabidopsis thaliana.Plant & cell physiology · 2026Article
- Genome-Wide Identification and Characterization of bHLH Family inLife (Basel, Switzerland) · 2026Article
- LL3, a homolog of LONESOME HIGHWAY, regulates vascular cell proliferation in the root apical meristem.Plant & cell physiology · 2026Article
- Mechanisms driving functional divergence of transcription factor paralogs.The New phytologist · 2025Review
- Genome-wide exploration of soybean domestication traits: integrating association mapping and SNP × SNP interaction analyses.Plant molecular biology · 2025Article
- The response to thermospermine is fine-tuned by the balance between SAC51 and LHW family proteins inFrontiers in plant science · 2025Article
- Characterization of genetic diversity and identification of genetic loci associated with carbon allocation in NBMC genomics · 2024Article
- SPL13 controls a root apical meristem phase change by triggering oriented cell divisions.Science (New York, N.Y.) · 2024Article
- Mapping the molecular landscape of Lotus japonicus nodule organogenesis through spatiotemporal transcriptomics.Nature communications · 2024Article
- Genetic basis of local adaptation in the cold-tolerant mangroveFrontiers in plant science · 2024Article
- Transcriptome and miRNAs Profiles Reveal Regulatory Network and Key Regulators of Secondary Xylem Formation in "84K" Poplar.International journal of molecular sciences · 2023Article
- Spatial regulation of plant hormone action.Journal of experimental botany · 2023Review
- Evolution and diversification of the ACT-like domain associated with plant basic helix-loop-helix transcription factors.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- HD-ZIP III-dependent local promotion of brassinosteroid synthesis suppresses vascular cell division in Arabidopsis root apical meristem.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The transcription factor AtMYB12 is part of a feedback loop regulating cell division orientation in the root meristem vasculature.Journal of experimental botany · 2023Article
- Identification of Transcriptional Networks Involved in De Novo Organ Formation in Tomato Hypocotyl Explants.International journal of molecular sciences · 2022Article
- bHLH heterodimer complex variations regulate cell proliferation activity in the meristems ofiScience · 2022Article
- Brassinosteroid signaling restricts root lignification by antagonizing SHORT-ROOT function in Arabidopsis.Plant physiology · 2022Article
- Deep origin and gradual evolution of transporting tissues: Perspectives from across the land plants.Plant physiology · 2022Article
- Pericycle cell division competence underlies various developmental programs.Plant biotechnology (Tokyo, Japan) · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Complex organisms consist of a multitude of cell types arranged in a precise spatial relation to each other. Arabidopsis roots generally exhibit radial tissue organization; however, within a tissue layer, cells are not identical. Specific vascular cell types are arranged in diametrically opposed longitudinal files that maximize the distance between them and create a bilaterally symmetric (diarch) root. Mutations in the LONESOME HIGHWAY (LHW) gene eliminate bilateral symmetry and reduce the number of cells in the center of the root, resulting in roots with only single xylem and phloem poles. LHW does not appear to be required for the creation of any specific cell type, but coordinately controls the number of all vascular cell types by regulating the size of the pool of cells from which they arise. We cloned LHW and found that it encodes a protein with weak sequence similarity to basic helix-loop-helix (bHLH)-domain proteins. LHW is a transcriptional activator in vitro. In plants, LHW is nuclear-localized and is expressed in the root meristems, where we hypothesize it acts independently of other known root-patterning genes to promote the production of stele cells, but might also indirectly feed into established regulatory networks for the maintenance of the root meristem.
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