ArticleNucleic acids research2007
Quantification of oxidative single-base and intrastrand cross-link lesions in unmethylated and CpG-methylated DNA induced by Fenton-type reagents.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
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- Fluorogenic labeling and single-base resolution analysis of 5-formylcytosine in DNA.Chemical science · 2017Article
- Comprehensive Assessment of Oxidatively Induced Modifications of DNA in a Rat Model of Human Wilson's Disease.Molecular & cellular proteomics : MCP · 2016Article
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- Hydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA.Nucleic acids research · 2014Article
- One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA.International journal of radiation biology · 2014Review
- Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism.Nucleic acids research · 2014Article
- Induction of 8,5'-cyclo-2'-deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents.Chemical research in toxicology · 2013Article
- Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA.Nucleic acids research · 2013Article
- Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism.Free radical biology & medicine · 2013Article
- DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase.The Journal of biological chemistry · 2012Article
- DNA damage by reactive species: Mechanisms, mutation and repair.Journal of biosciences · 2012Review
- Structural, energetic and dynamic properties of guanine(C8)-thymine(N3) cross-links in DNA provide insights on susceptibility to nucleotide excision repair.Nucleic acids research · 2012Article
- Radiation protection following nuclear power accidents: a survey of putative mechanisms involved in the radioprotective actions of taurine during and after radiation exposure.Microbial ecology in health and disease · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Methylation of cytosine at CpG sites in mammalian cells plays an important role in the epigenetic regulation of gene expression. Here, we assessed the formation of single-nucleobase lesions and intrastrand cross-link lesions (i.e. G[8-5]C, C[5-8]G, mC[5m-8]G, and G[8-5m]mC, where 'mC' represents 5-methylcytosine) in unmethylated and the corresponding CpG-methylated synthetic double-stranded DNA upon treatment with Fenton-type reagents [i.e. H2O2, ascorbate together with Cu(II) or Fe(II)]. Our results showed that the yields of oxidative single-nucleobase lesions were considerably higher than those of the intrastrand cross-link lesions. Although no significant differences were found for the yields of single-base lesions induced from cytosine and mC, the G[8-5m]mC cross-link was induced approximately 10 times more efficiently than the G[8-5]C cross-link. In addition, the mC[5m-8]G was induced at a level that was approximately 15 times less than G[8-5m]mC, whereas the corresponding C[5-8]G intrastrand cross-link lesion was not detectable. Moreover, Cu(II) is approximately 10-fold as effective as Fe(II) in inducing oxidative DNA lesions. These results suggest that oxidative intrastrand cross-link lesions formed at methylated-CpG sites may account for the previously reported mCG-->TT tandem double mutations induced by Fenton-type reagents.
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