ReviewJournal of the Royal Society, Interface2007
The dynamic influence of genetic variation on the susceptibility of sheep to gastrointestinal nematode infection.
Review in Journal of the Royal Society, Interface, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Parasite abundance distribution as a model of host-parasite relationships between monogeneans Gyrodactylus spp. and cage-reared rainbow trout Oncorhynchus mykiss.Parasitology research · 2024Article
- Extensive Sheep and Goat Production: The Role of Novel Technologies towards Sustainability and Animal Welfare.Animals : an open access journal from MDPI · 2022Review
- Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach.PLoS neglected tropical diseases · 2020Article
- A comparison of helminth infections as assessed through coprological analysis and adult worm burdens in a wild host.International journal for parasitology. Parasites and wildlife · 2018Article
- Implementation of an extended ZINB model in the study of low levels of natural gastrointestinal nematode infections in adult sheep.BMC veterinary research · 2016Article
- A Bayesian generalized random regression model for estimating heritability using overdispersed count data.Genetics, selection, evolution : GSE · 2015Article
- Multitrait indices to predict worm length and number in sheep with natural, mixed predominantly Teladorsagia circumcincta infection.Parasitology · 2015Article
- An explicit immunogenetic model of gastrointestinal nematode infection in sheep.Journal of the Royal Society, Interface · 2014Article
- Functional investigation of a QTL affecting resistance to Haemonchus contortus in sheep.Veterinary research · 2014Article
- The influence of MHC and immunoglobulins a and e on host resistance to gastrointestinal nematodes in sheep.Journal of parasitology research · 2011Article
- Model or meal? Farm animal populations as models for infectious diseases of humans.Nature reviews. Microbiology · 2010Review
- Modelling heterogeneity and the impact of chemotherapy and vaccination against human hookworm.Journal of the Royal Society, Interface · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interaction between sheep and the nematode Teladorsagia circumcincta is one of the best understood of all host-parasite interactions. Following infection, there is considerable variation among lambs in the number of nematode eggs produced, the number of early fourth-stage larvae and the number of adult worms in the mucosa. These traits have a high variance to mean ratio (i.e. they are overdispersed or aggregated among hosts), they are skewed and approximately negative binomially distributed. The sources of overdispersion are differences among lambs in the ingestion of infective larvae and the immune response. Both forces can produce aggregation but their relative importance is unknown. The key components of variation can be identified by variance analysis. The sum of the average effects of polymorphic genes is known as additive genetic variation and this increases essentially from zero at one month of age to quite high values at six months of age. The major mechanism underlying genetic variation appears to be the differences among individuals in immune responses. Two of the major sources of variation in immune responses are differences in antigen recognition and differences in the type of cytokines produced. Genes that influence both these sources of variation are associated with differences in resistance to nematode infection. Therefore, much of the heterogeneity among animals in parasite transmission appears to be due to genetic variation in immune responsiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.