ArticleFungal genetics and biology : FG & B2007
Analysis of ALS5 and ALS6 allelic variability in a geographically diverse collection of Candida albicans isolates.
Article in Fungal genetics and biology : FG & B, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Use of aFrontiers in cellular and infection microbiology · 2024Article
- Amino acid substitutions in specific proteins correlate with farnesol unresponsiveness in Candida albicans.BMC genomics · 2023Article
- Prevalence, Molecular Identification, and Genotyping ofAdvanced biomedical research · 2022Article
- Using Genomics to Shape the Definition of the Agglutinin-Like Sequence (Frontiers in cellular and infection microbiology · 2021Article
- Mechanisms of genome evolution in Candida albicans.Current opinion in microbiology · 2019Review
- Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Biological Roles of Protein-Coding Tandem Repeats in the YeastJournal of fungi (Basel, Switzerland) · 2018Article
- Article
- Candida albicans Agglutinin-Like Sequence (Als) Family Vignettes: A Review of Als Protein Structure and Function.Frontiers in microbiology · 2016Review
- Candida species biofilm and Candida albicans ALS3 polymorphisms in clinical isolates.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Characterization of genetic determinants that modulate Candida albicans filamentation in the presence of bacteria.PloS one · 2013Article
- Functional divergence of gene duplicates through ectopic recombination.EMBO reports · 2012Article
- Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype.Journal of clinical microbiology · 2011Article
- ALS51, a newly discovered gene in the Candida albicans ALS family, created by intergenic recombination: analysis of the gene and protein, and implications for evolution of microbial gene families.FEMS immunology and medical microbiology · 2011Article
- Candida albicans Als3, a multifunctional adhesin and invasin.Eukaryotic cell · 2011Review
- Candida albicans: genotyping methods and clade related phenotypic characteristics.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
- The Aspergillus fumigatus cspA gene encoding a repeat-rich cell wall protein is important for normal conidial cell wall architecture and interaction with host cells.Eukaryotic cell · 2010Article
- On the evolution of fungal and yeast cell walls.Yeast (Chichester, England) · 2010Review
- Candida infections of the genitourinary tract.Clinical microbiology reviews · 2010Review
- Impact of genetic background on allele selection in a highly mutable Candida albicans gene, PNG2.PloS one · 2010Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The Candida albicans ALS (agglutinin-like sequence) gene family encodes eight cell-surface glycoproteins, some of which function in adhesion to host surfaces. ALS genes have a central tandem repeat-encoding domain comprised entirely of head-to-tail copies of a conserved 108-bp sequence. The number of copies of the tandemly repeated sequence varies between C. albicans strains and often between alleles within the same strain. Because ALS alleles can encode different-sized proteins that may have different functional characteristics, defining the range of allelic variability is important. Genomic DNA from C. albicans strains representing the major genetic clades was PCR amplified to determine the number of tandemly repeated sequence copies within the ALS5 and ALS6 central domain. ALS5 alleles had 2-10 tandem repeat sequence copies (mean=4.82 copies) while ALS6 alleles had 2-8 copies (mean=4.00 copies). Despite this variability, tandem repeat copy number was stable in C. albicans strains passaged for 3000 generations. Prevalent alleles and allelic distributions varied among the clades for ALS5 and ALS6. Overall, ALS6 exhibited less variability than ALS5. ALS5 deletions can occur naturally in C. albicans via direct repeats flanking the ALS5 locus. Deletion of both ALS5 alleles was associated particularly with clades III and SA. ALS5 exhibited allelic polymorphisms in the coding region 5' of the tandem repeats; some alleles resembled ALS1, suggesting recombination between these contiguous loci. Natural deletion of ALS5 and the sequence variation within its coding region suggest relaxed selective pressure on this locus, and that Als5p function may be dispensable in C. albicans or redundant within the Als family.
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