Evidence map›Paper›PMID 17625709›Full record

SynthesisSao Paulo medical journal = Revista paulista de medicina2007

Does sodium nitroprusside kill babies? A systematic review.

Nelson Sass, Caroline Harumi Itamoto, Marina Pereira Silva, Maria Regina Torloni, Alvaro Nagib Atallah

Open access · diamondAbstract readSystematic Review
In one paragraph

Synthesis in Sao Paulo medical journal = Revista paulista de medicina, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Guideline
  2. Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  3. Brazilian Guidelines of Hypertension - 2020.Arquivos brasileiros de cardiologia · 2021
    Article
  4. Management of Heart Failure and Cardiogenic Shock in Pregnancy.Current treatment options in cardiovascular medicine · 2019
    Review
  5. Hypertension in pregnancy.Current atherosclerosis reports · 2014
    Review
  6. How to manage hypertension in pregnancy effectively.British journal of clinical pharmacology · 2011
    Review
  7. Control of hypertension in pregnancy.Current hypertension reports · 2009
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nelson SassObstetrics Department, Universidade Federal de São Paulo Escola Paulista de Medicina, Brazil. nelsonsa.alp@terra.com.br
Caroline Harumi Itamoto
Marina Pereira Silva
Maria Regina Torloni
Alvaro Nagib Atallah
Universidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether sodium nitroprusside causes fetal death in pregnancies complicated with hypertension. DATA SOURCES: Medical Literature Analysis and Retrieval System Online (MEDLINE; 1996 to 2003), Excerpta Medica (EMBASE; 1970 to 2003), Web of Science/Institute for Scientific Information (ISI; 1945 to 2003), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS; 1982 to 2003) and the Cochrane Library. REVIEW

methodsThe medical subject headings used were "nitroprusside and pregnancy", "hypertension or eclampsia or preeclampsia" and "nitroprusside and pregnancy and hypertensive emergencies". The search was limited to humans and female gender, in all fields, publication types, languages and subsets. Articles were also identified by reviewing the references of articles and textbooks on hypertension and pregnancy.

resultsThe search located nine studies. The sum of all the publications yielded a total of 22 patients and 24 exposed fetuses (two pairs of twins). There were no randomized clinical trials and no prospective cohorts. All of the studies were observational in nature.

conclusionsAt present, there is insufficient evidence for definitive conclusions about any direct association between sodium nitroprusside use and fetal demise.

Indexed as

Antihypertensive AgentsFemaleFetal DeathHumansHypertensionNitroprussidePregnancyPregnancy Complications, CardiovascularPregnancy OutcomeAntihypertensive AgentsNitroprusside

Identifiers

PMID17625709
PMCPMC11014698
OpenAlexW2001395268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.