ReviewStem cell reviews2006
Pluripotent stem cells and their niches.
Review in Stem cell reviews, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Proteomic Analysis of Nucleus Pulposus Cell-derived Extracellular Matrix Niche and Its Effect on Phenotypic Alteration of Dermal Fibroblasts.Scientific reports · 2018Article
- Three Dimensional Honeycomb Patterned Fibrinogen Based Nanofibers Induce Substantial Osteogenic Response of Mesenchymal Stem Cells.Scientific reports · 2017Article
- Integrin and FAK Regulation of Human Pluripotent Stem Cells.Current stem cell reports · 2017Review
- Macromolecular crowding meets oxygen tension in human mesenchymal stem cell culture - A step closer to physiologically relevant in vitro organogenesis.Scientific reports · 2016Article
- Intraperitoneal Injection of Multiplacentas Pooled Cells Treatment on a Mouse Model with Aplastic Anemia.Stem cells international · 2016Article
- Evidence for self-maintaining pluripotent murine stem cells in embryoid bodies.Stem cell reviews and reports · 2014Article
- Sinus lift tissue engineering using autologous pulp micro-grafts: A case report of bone density evaluation.Journal of Indian Society of Periodontology · 2013Article
- Isolation and characterization of chorionic mesenchymal stromal cells from human full term placenta.Journal of Korean medical science · 2012Article
- The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells.PloS one · 2012Article
- Cell- and gene-based therapeutic approaches for neurological deficits in mucopolysaccharidoses.Current pharmaceutical biotechnology · 2011Review
- The PluriNetWork: an electronic representation of the network underlying pluripotency in mouse, and its applications.PloS one · 2010Article
- Induction of bone formation by transforming growth factor-beta2 in the non-human primate Papio ursinus and its modulation by skeletal muscle responding stem cells.Cell proliferation · 2010Article
- Challenges in cardiac tissue engineering.Tissue engineering. Part B, Reviews · 2010Review
- Reconstitution of mammary epithelial morphogenesis by murine embryonic stem cells undergoing hematopoietic stem cell differentiation.PloS one · 2010Article
- Biomimetism, biomimetic matrices and the induction of bone formation.Journal of cellular and molecular medicine · 2009Review
- Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support.Journal of cellular and molecular medicine · 2009Article
- Stem cells in the trabecular meshwork: present and future promises.Experimental eye research · 2009Review
- c-Kit+ bone marrow stem cells differentiate into functional cardiac myocytes.Clinical and translational science · 2009Article
- The epigenetic influence of tumor and embryonic microenvironments: how different are they?Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2008Article
- Evolution of the c-kit-positive cell response to pathological challenge in the myocardium.Stem cells (Dayton, Ohio) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of stem cells to self-renew and to replace mature cells is fundamental to ontogeny and tissue regeneration. Stem cells of the adult organism can be categorized as mono-, bi-, or multipotent, based on the number of mature cell types to which they can give rise. In contrast, pluripotent stem cells of the early embryo have the ability to form every cell type of the adult body. Permanent lines of pluripotent stem cells have been derived from preimplantation embryos (embryonic stem cells), fetal primordial germ cells (embryonic germ cells), and malignant teratocarcinomas (embryonal carcinoma cells). Cultured pluripotent stem cells can easily be manipulated genetically, and they can be matured into adult-type stem cells and terminally differentiated cell types in vitro, thereby, providing powerful model systems for the study of mammalian embryogenesis and disease processes. In addition, human embryonic stem cell lines hold great promise for the development of novel regenerative therapies. To fully utilize the potential of these cells, we must first understand the mechanisms that control pluripotent stem cell fate and function. In recent decades, the microenvironment or niche has emerged as particularly critical for stem cell regulation. In this article, we review how pluripotent stem cell signal transduction mechanisms and transcription factor circuitries integrate information provided by the microenvironment. In addition, we consider the potential existence and location of adult pluripotent stem cell niches, based on the notion that a revealing feature indicating the presence of stem cells in a given tissue is the occurrence of tumors whose characteristics reflect the normal developmental potential of the cognate stem cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.