ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2007
Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Intravitreal vascular endothelial growth factor and connective tissue growth factor levels and risk factors associated with vitreous hemorrhage in proliferative diabetic retinopathy after pan-retinal laser photocoagulation: a cross-sectional study.International journal of retina and vitreous · 2026Article
- Eyeing the Extracellular Matrix in Vascular Development and Microvascular Diseases and Bridging the Divide between Vascular Mechanics and Function.International journal of molecular sciences · 2020Review
- CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Emerging roles of CCN proteins in vascular development and pathology.Journal of cell communication and signaling · 2016Article
- Retinal fibrosis in diabetic retinopathy.Experimental eye research · 2016Review
- Transplanted Umbilical Cord Mesenchymal Stem Cells Modify the In Vivo Microenvironment Enhancing Angiogenesis and Leading to Bone Regeneration.Stem cells and development · 2015Article
- Increased adipose tissue hypoxia and capacity for angiogenesis and inflammation in young diet-sensitive C57 mice compared with diet-resistant FVB mice.International journal of obesity (2005) · 2013Article
- Increased expression of CCN2 in the red flashing light-induced myopia in guinea pigs.BioMed research international · 2013Article
- Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene.The Journal of biological chemistry · 2012Article
- Role of connective tissue growth factor in the retinal vasculature during development and ischemia.Investigative ophthalmology & visual science · 2011Article
- Roles for CCN2 in normal physiological processes.Cellular and molecular life sciences : CMLS · 2011Review
- CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis.Critical reviews in eukaryotic gene expression · 2011Review
- Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling.Arthritis and rheumatism · 2010Article
- Temporal and spatial expression of CCN genes in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Differential regulation of connective tissue growth factor in renal cells by histone deacetylase inhibitors.Journal of cellular and molecular medicine · 2009Article
- CTGF is increased in basal deposits and regulates matrix production through the ERK (p42/p44mapk) MAPK and the p38 MAPK signaling pathways.Investigative ophthalmology & visual science · 2009Article
- Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo.Journal of cell communication and signaling · 2009Article
- Article
- Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopenia.Endocrinology · 2008Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Connective tissue growth factor (CTGF) is a member of the CCN family of growth factors. CTGF is important in scarring, wound healing, and fibrosis. It has also been implicated to play a role in angiogenesis, in addition to vascular endothelial growth factor (VEGF). In the eye, angiogenesis and subsequent fibrosis are the main causes of blindness in conditions such as diabetic retinopathy. We have applied three different models of angiogenesis to homozygous CTGF(-/-) and heterozygous CTGF(+/-) mice to establish involvement of CTGF in neovascularization. CTGF(-/-) mice die around birth. Therefore, embryonic CTGF(-/-), CTGF(+/-), and CTGF(+/+) bone explants were used to study in vitro angiogenesis, and neonatal and mature CTGF(+/-) and CTGF(+/+) mice were used in models of oxygen-induced retinopathy and laser-induced choroidal neovascularization. Angiogenesis in vitro was independent of the CTGF genotype in both the presence and the absence of VEGF. Oxygen-induced vascular pathology in the retina, as determined semi-quantitatively, and laser-induced choroidal neovascularization, as determined quantitatively, were also not affected by the CTGF genotype. Our data show that downregulation of CTGF levels does not affect neovascularization, indicating distinct roles of VEGF and CTGF in angiogenesis and fibrosis in eye conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.