ArticleStatistics in medicine2008
Youden Index and the optimal threshold for markers with mass at zero.
Article in Statistics in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.
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Who cites it
103 citing papers in PubMed, 1 synthesis or guideline pooled it.
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- FIB-4 index predicts short-term mortality in Vietnamese acute heart failure patients.American heart journal plus : cardiology research and practice · 2026Article
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- Evaluation of pre-Omicron population immunity for SARS-CoV-2 in the Household Influenza Vaccine Evaluation (HIVE) cohort.PloS one · 2026Article
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- Development and validation of enzyme-linked immunosorbent assays for the serodiagnosis of canine bartonelloses.Journal of clinical microbiology · 2025Article
- Organic geochemical evidence for life in Archean rocks identified by pyrolysis-GC-MS and supervised machine learning.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Association Between Brain Temperature and Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Who Received Targeted Temperature Management at 33 °C.Reviews in cardiovascular medicine · 2025Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The Youden Index is often used as a summary measure of the receiver operating characteristic curve. It measures the effectiveness of a diagnostic marker and permits the selection of an optimal threshold value or cutoff point for the biomarker of interest. Some markers, while basically continuous and positive, have a spike or positive mass of probability at the value zero. We provide a flexible modeling approach for estimating the Youden Index and its associated cutoff point for such spiked data and compare it with the standard empirical approach. We show how this modeling approach can be adjusted to take covariate information into account. This approach is applied to data on the Coronary Calcium Score, a marker for atherosclerosis.
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Registered trials
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