ArticleExperimental gerontology2007
Adipogenic signaling in rat white adipose tissue: modulation by aging and calorie restriction.
Article in Experimental gerontology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
- Co-overexpression of the caloric restriction-induced mitochondrial factors PGC-1α and MIPEP upregulates Phospho1 expression in adipocytes.FEBS open bio · 2025Article
- Aging and homeostasis of the hypodermis in the age-related deterioration of skin function.Cell death & disease · 2024Review
- Identification of candidate proteins regulated by long-term caloric restriction and feed efficiency inJournal of animal science and technology · 2022Article
- Aging-dependent regulatory cells emerge in subcutaneous fat to inhibit adipogenesis.Developmental cell · 2021Article
- Involvement of PPARγ/FSP27 in the pathogenic mechanism underlying insulin resistance: tipping the balance between lipogenesis and fat storage in adult catch-up growth rats.Nutrition & metabolism · 2019Article
- SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction.International journal of molecular sciences · 2018Review
- Article
- Maintaining physical activity during refeeding improves body composition, intestinal hyperpermeability and behavior in anorectic mice.Scientific reports · 2016Article
- A Moderate Low-Carbohydrate Low-Calorie Diet Improves Lipid Profile, Insulin Sensitivity and Adiponectin Expression in Rats.Nutrients · 2015Article
- Citrulline counteracts overweight- and aging-related effects on adiponectin and leptin gene expression in rat white adipose tissue.Biochimie open · 2015Article
- Article
- C/EBPβ Isoforms Expression in the Rat Brain during the Estrous Cycle.International journal of endocrinology · 2015Article
- Impact of caloric restriction on myocardial ischaemia/reperfusion injury and new therapeutic options to mimic its effects.British journal of pharmacology · 2014Article
- Sudden decrease in physical activity evokes adipocyte hyperplasia in 70- to 77-day-old rats but not 49- to 56-day-old rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Article
- Weight control and cancer preventive mechanisms: role of insulin growth factor-1-mediated signaling pathways.Experimental biology and medicine (Maywood, N.J.) · 2013Review
- Serum from calorie-restricted rats activates vascular cell eNOS through enhanced insulin signaling mediated by adiponectin.PloS one · 2012Article
- Diet and aging.Oxidative medicine and cellular longevity · 2012Review
- Liver-enriched inhibitory protein (LIP) actively inhibits preadipocyte differentiation through histone deacetylase 1 (HDAC1).The Journal of biological chemistry · 2011Article
- Caloric restriction attenuates the age-associated increase of adipose-derived stem cells but further reduces their proliferative capacity.Age (Dordrecht, Netherlands) · 2011Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Alterations in adipogenesis could have significant impact on several aging processes. We previously reported that calorie restriction (CR) in rats significantly increases the level of circulating adiponectin, a distinctive marker of differentiated adipocytes, leading to a concerted modulation in the expression of key transcription target genes and, as a result, to increased fatty acid oxidation and reduced deleterious lipid accumulation in other tissues. These findings led us to investigate further the effects of aging on adipocytes and to determine how CR modulates adipogenic signaling in vivo. CR for 2 and 25 months, significantly increased the expression of PPARgamma, C/EBPbeta and Cdk-4, and partially attenuated age-related decline in C/EBPalpha expression relative to rats fed ad libitum (AL). As a result, adiponectin was upregulated at both mRNA and protein levels, resulting in activation of target genes involved in fatty acid oxidation and fatty acid synthesis, and greater responsiveness of adipose tissue to insulin. Moreover, CR significantly decreased the ratio of C/EBPbeta isoforms LAP/LIP, suggesting the suppression of gene transcription associated with terminal differentiation while facilitating preadipocytes proliferation. Morphometric analysis revealed a greater number of small adipocytes in CR relative to AL feeding. Immunostaining confirmed that small adipocytes were more strongly positive for adiponectin than the large ones. Overall these results suggest that CR increased the expression of adipogenic factors, and maintained the differentiated state of adipocytes, which is critically important for adiponectin biosynthesis and insulin sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.