ReviewToxicology letters2007
Cytokines and other immunological biomarkers in children's environmental health studies.
Review in Toxicology letters, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 104 citations in OpenAlex.
- Review
- Blood-Based Biomarkers for Managing Workload in Athletes: Perspectives for Research on Emerging Biomarkers.Sports medicine (Auckland, N.Z.) · 2023Review
- Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth.Croatian medical journal · 2023Article
- Article
- Stage-Dependent Increase of Systemic Immune Activation and CCR5Pathogens (Basel, Switzerland) · 2023Article
- Mechanisms of Immunotoxicity: Stressors and Evaluators.International journal of molecular sciences · 2021Review
- Poverty and Targeted Immunotherapy: Survival in Children's Oncology Group Clinical Trials for High-Risk Neuroblastoma.Journal of the National Cancer Institute · 2021Article
- Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches.Nanomaterials (Basel, Switzerland) · 2020Review
- Potential role of N-acetylcysteine on chlorpyrifos-induced neurotoxicity in rats.Environmental science and pollution research international · 2019Article
- Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals.Immunity & ageing : I & A · 2017Article
- Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases (Review).International journal of molecular medicine · 2016Review
- Age-Related Changes in Immunological Factors and Their Relevance in Allergic Disease Development During Childhood.Allergy, asthma & immunology research · 2016Article
- Influence of diet, vitamin, tea, trace elements and exogenous antioxidants on arsenic metabolism and toxicity.Environmental geochemistry and health · 2016Review
- Protective effect of Emblica-officinalis in arsenic induced biochemical alteration and inflammation in mice.SpringerPlus · 2015Article
- Mechanisms of Heightened Airway Sensitivity and Responses to Inhaled SO2 in Asthmatics.Environmental health insights · 2015Review
- Home renovation, family history of atopy, and respiratory symptoms and asthma among children living in China.American journal of public health · 2014Article
- Proliferation and TH1/TH2 cytokine production in human peripheral blood mononuclear cells after treatment with cypermethrin and mancozeb in vitro.Journal of toxicology · 2014Article
- The role of environmental factors in modulating immune responses in early life.Frontiers in immunology · 2014Review
- Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines.Journal of controlled release : official journal of the Controlled Release Society · 2013Review
- Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health.The British journal of nutrition · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Environmental exposures (e.g. pesticides, air pollution, and environmental tobacco smoke) during prenatal and early postnatal development have been linked to a growing number of childhood diseases including allergic disorders and leukemia. Because the immune response plays a critical role in each of these diseases, it is important to study the effects of toxicants on the developing immune system. Children's unique susceptibility to environmental toxicants has become an important focus of the field of immunotoxicology and the use of immune biomarkers in molecular epidemiology of children's environmental health is a rapidly expanding field of research. In this review, we discuss how markers of immune status and immunotoxicity are being applied to pediatric studies, with a specific focus on the various methods used to analyze T-helper-1/2 (Th1/Th2) cytokine profiles. Furthermore, we review recent data on the effects of children's environmental exposures to volatile organic compounds, metals, and pesticides on Th1/Th2 cytokine profiles and the associations of Th1/Th2 profiles with adverse health outcomes such as pediatric respiratory diseases, allergies, cancer and diabetes. Although cytokine profiles are increasingly used in children's studies, there is still a need to acquire distribution data for different ages and ethnic groups of healthy children. These data will contribute to the validation and standardization of cytokine biomarkers for future studies. Application of immunological markers in epidemiological studies will improve the understanding of mechanisms that underlie associations between environmental exposures and immune-mediated disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.