ArticleDevelopment genes and evolution2007
Evolution of the Groucho/Tle gene family: gene organization and duplication events.
Article in Development genes and evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Maternal effect factors that contribute to oocytes developmental competence: an update.Journal of assisted reproduction and genetics · 2022Review
- Identification of Novel BiallelicFrontiers in genetics · 2021Article
- Article
- AES/GRG5: more than just a dominant-negative TLE/GRG family member.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Review
- Article
- Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation.Development (Cambridge, England) · 2010Article
- A subcortical maternal complex essential for preimplantation mouse embryogenesis.Developmental cell · 2008Article
- The Groucho/TLE/Grg family of transcriptional co-repressors.Genome biology · 2008Article
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Authors and funding
1 author.
Funding
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Abstract
The Groucho/Tle family of corepressor proteins has important roles in development and in adult tissue in both Protostomes and Deuterostomes. In Drosophila, a single member of this family has been identified. Unlike in Protostomes, most Deutrostomes contain more than two full-length Tle genes. In this study, I analyse the genomic organization and phylogenetic relationship between the long and short forms of the Groucho/Tle family members in Chordata. The genomic location and sequence similarities suggest that Aes/Grg5 and Tle6/Grg6 arose from duplication of the Tle2 gene; each evolved independently and acquired new functions as negative regulators of the other Tle proteins. Based on these data, a model for Groucho/Tle gene evolution is proposed.
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Registered trials
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