ArticleVirus research2007
Dysregulated interferon-gamma responses during lethal cytomegalovirus brain infection of IL-10-deficient mice.
Article in Virus research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 34 citations in OpenAlex.
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- Programmed death ligand-1 induction restrains the cytotoxic T lymphocyte response against microglia.Glia · 2021Article
- Sirtuin 5 is Dispensable for CD8Frontiers in cell and developmental biology · 2021Article
- Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation.Frontiers in cellular neuroscience · 2021Article
- Antiallodynic Effects of Cannabinoid Receptor 2 (CBPain research & management · 2019Article
- Reactive glia promote development of CD103Immunity, inflammation and disease · 2018Article
- Nitrosative damage during retrovirus infection-induced neuropathic pain.Journal of neuroinflammation · 2018Article
- The PD-1: PD-L1 pathway promotes development of brain-resident memory T cells following acute viral encephalitis.Journal of neuroinflammation · 2017Article
- Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection.Scientific reports · 2017Article
- Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection.Journal of neuroinflammation · 2016Article
- Ethanol-Induced TLR4/NLRP3 Neuroinflammatory Response in Microglial Cells Promotes Leukocyte Infiltration Across the BBB.Neurochemical research · 2016Article
- Chronic reactive gliosis following regulatory T cell depletion during acute MCMV encephalitis.Glia · 2015Article
- Immunobiology of congenital cytomegalovirus infection of the central nervous system—the murine cytomegalovirus model.Cellular & molecular immunology · 2015Review
- Tregs Modulate Lymphocyte Proliferation, Activation, and Resident-Memory T-Cell Accumulation within the Brain during MCMV Infection.PloS one · 2015Article
- Infiltrating regulatory B cells control neuroinflammation following viral brain infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Persistent humoral immune responses in the CNS limit recovery of reactivated murine cytomegalovirus.PloS one · 2012Article
- Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ.Journal of neurovirology · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Murine cytomegalovirus (MCMV) brain infection induces a transient increase in chemokine production, which precedes the infiltration of CD3(+) lymphocytes. In this study, we hypothesized that an absence of anti-inflammatory cytokines would result in sustained proinflammatory neuroimmune responses. Direct intracerebroventricular injection of MCMV into IL-10 knockout (KO) mice produced an unexpected result: while wild-type animals controlled MCMV, the infection was lethal in IL-10 KO animals. Identical infection of IL-4 KO animals did not produce lethal disease. To further characterize the role of IL-10, infected brain tissue from both wild-type and IL-10 KO animals was assessed for cytokine and chemokine levels, as well as viral gene expression. These data show vastly elevated levels of interferon (IFN)-gamma, and the IFN-gamma-inducible chemokines CXCL9 and CXCL10, as well as IL-6 in brain homogenates obtained from IL-10 KO animals. However, MCMV viral load, glycoprotein B mRNA levels, and titers of infectious virus were similar in both IL-10 KO and wild-type animals. Separation of cells isolated from murine brain tissue into distinct populations using FACS, along with subsequent quantitative RT real-time PCR, showed that brain-infiltrating CD45(hi)/CD11b(-) and CD45(hi)/CD11b(int) were the cellular source of IL-10 in the brain. Taken together, these data demonstrate that MCMV brain infection of IL-10-deficient mice causes lethal disease, which occurs in the presence of a dysregulated IFN-gamma-mediated neuroimmune response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.