Evidence map›Paper›PMID 17624183›Full record

ArticleBiomedical and environmental sciences : BES2007

Effects of copper-phenanthroline on pentachlorophenol-induced adaptation and cell death of Escherichia coli.

Xue-Wen Zhang, Rong-Gui Li, Xin Wang, Shuan-Hu Zhou

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Biomedical and environmental sciences : BES, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xue-Wen ZhangDepartment of Biology, Qingdao University, Qingdao 266071, Shandong, China.
Rong-Gui Li
Xin Wang
Shuan-Hu Zhou
Qingdao University · CN

Funding

Identification of Novel Drugs against Huntington's Disease and Cerebral IschemiaK01NS055072 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI WANG, XIN · 2007 to 2011
$885k
NINDS NIH HHS K01 NS055072NINDS NIH HHS K01NS055072
6 · The paper itself

Abstract

objectiveTo evaluate the effects of copper-phenanthroline (CuOP) on pentachlorophenol (PCP)-induced adaptation and cell death of Escherichia coli.

methodsBacterial growth and adaptation to PCP were monitored spectrophotometrically at 600 nm. Inactivation of bacterial cells was determined from colony count on agar dishes. Cellular ATP content and accumulation of PCP were assessed by chemiluminescence and HPLC analysis respectively. The formation of PCP-Cu-OP complex was shown by UV-visible spectra.

resultsEscherichia coli (E. coli) could adapt to PCP, a wood preservative and insecticide used in agriculture. The adaptation of E. coli to PCP prevented its death to the synergistic cytotoxicity of CuOP plus PCP and declined cellular accumulation and uncoupling of oxidative phosphorylation of PCP. Furthermore, CuOP and PCP neither produced reactive oxygen species (ROS) nor had a synergistic effect on uncoupling of oxidative phosphorylation in E. coli. The synergistic cytotoxicity of CuOP and PCP in E. coli might be due to the formation of lipophilic PCP-Cu-OP complex.

conclusionOur data suggested that adaptation of E. coli to PCP decreased the synergistic effects of CuOP and PCP on prokaryotic cell death due to the formation of lipophilic PCP-Cu-OP complex, but it had no effect on the uncoupling of oxidative phosphorylation and production of reactive oxygen species in E. coli.

Indexed as

Adaptation, PhysiologicalAdenosine TriphosphateAntioxidantsApoptosisCopperCytotoxinsDrug Resistance, BacterialDrug SynergismEscherichia coliPentachlorophenolPhenanthrolines1,10-phenanthrolineAdenosine TriphosphateAntioxidantsCopperCytotoxinsPentachlorophenolPhenanthrolines

Identifiers

PMID17624183
PMCPMC2729107
OpenAlexW2099839159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.