ArticleGenome research2007
Recombination rate estimation in the presence of hotspots.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers.
What it found
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Who cites it
169 citing papers in PubMed.
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- Inferring fine-scale rates of mutation and recombination in the coppery titi monkey (Plecturocebus cupreus).Heredity · 2026Article
- Natural selection and recombination interact to structure genome-wide variation in pines.The Plant journal : for cell and molecular biology · 2026Article
- Augmented CENH3 loading is accompanied by transcriptional and epigenetic reprogramming at rice centromeres during meiosis.Genome biology · 2026Article
- GENERAL MOMENT CLOSURE FOR THE NEUTRAL TWO-LOCUS WRIGHT-FISHER DYNAMICS.bioRxiv : the preprint server for biology · 2026Article
- Fine-scale recombination rates inferred using the canFam4 assembly are strongly correlated with previous maps of dog recombination.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Inferring Fine-Scale Mutation and Recombination Rate Maps in Aye-Ayes (Ecology and evolution · 2025Article
- Genealogical Analysis of Replicate Flower Colour Hybrid Zones in Antirrhinum.Molecular ecology · 2025Article
- Haplotype-resolved genomics identifiesiScience · 2025Article
- The genetics of extrinsic postzygotic selection in a migratory divide between subspecies of the Swainson's thrush.Nature communications · 2025Article
- The Density of Recombination-Associated Genomic Features Does Not Generally Explain the Broad-Scale Crossover Patterns in Chicken and Guinea Fowl.Animals : an open access journal from MDPI · 2025Article
- Sex-biased Migration and Demographic History of the Big European Firefly Lampyris noctiluca.Molecular biology and evolution · 2025Article
- Unexpectedly low recombination rates and presence of hotspots in termite genomes.Genome research · 2025Article
- Leveraging Whole Genomes, Mitochondrial DNA and Haploblocks to Decipher Complex Demographic Histories: An Example From a Broadly Admixed Arctic Fish.Molecular ecology · 2025Article
- Recombination and transposition drive genomic structural variation potentially impacting life history traits in a host-generalist fungal plant pathogen.BMC biology · 2025Article
- Developing a crop- wild-reservoir pathogen system to understand pathogen evolution and emergence.eLife · 2025Article
- Sexual selection, genomic evolution and population fitness inProceedings. Biological sciences · 2025Article
- Repeatable Selection on Large Ancestry Blocks in an Avian Hybrid Zone.Molecular biology and evolution · 2025Article
- Article
109 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fine-scale estimation of recombination rates remains a challenging problem. Experimental techniques can provide accurate estimates at fine scales but are technically challenging and cannot be applied on a genome-wide scale. An alternative source of information comes from patterns of genetic variation. Several statistical methods have been developed to estimate recombination rates from randomly sampled chromosomes. However, most such methods either make poor assumptions about recombination rate variation, or simply assume that there is no rate variation. Since the discovery of recombination hotspots, it is clear that recombination rates can vary over many orders of magnitude at the fine scale. We present a method for the estimation of recombination rates in the presence of recombination hotspots. We demonstrate that the method is able to detect and accurately quantify recombination rate heterogeneity, and is a substantial improvement over a commonly used method. We then use the method to reanalyze genetic variation data from the HLA and MS32 regions of the human genome and demonstrate that the method is able to provide accurate rate estimates and simultaneously detect hotspots.
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