ArticleProceedings of the National Academy of Sciences of the United States of America2007
Tomato MAPKs LeMPK1, LeMPK2, and LeMPK3 function in the systemin-mediated defense response against herbivorous insects.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
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110 citing papers in PubMed, 272 citations in OpenAlex.
- Mycorrhiza-induced resistance against Botrytis cinerea in tomato operates through the systemin signalling cascade.The New phytologist · 2026Article
- Comparative proteomics provides Insights into activation of jasmonic acid-mediated resistance mechanism in chickpea-Helicoverpa armigera interaction.Plant cell reports · 2026Article
- Transcriptome analysis coupled with virus induced gene silencing delineates the unfolded protein response of tomato.Molecular genetics and genomics : MGG · 2026Article
- Overexpression of GhAAP3 increases Helicoverpa armigera feeding by altering hormonal and metabolic composition in cotton.Plant cell reports · 2026Article
- Robustness in jasmonate signaling: mechanisms of concerted regulation and implications for crop improvement.aBIOTECH · 2025Review
- BpWRKY6 regulates insect resistance by affecting jasmonic acid and terpenoid synthesis in Betula platyphylla.Plant biotechnology journal · 2025Article
- Blooming resilience: transcriptomic insights into cotton flower responses to boll weevil infestation.Plant cell reports · 2025Article
- Structure-Function Analysis of Volatile (Z)-3-Fatty Alcohols in Tomato.Journal of chemical ecology · 2025Article
- Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses.Frontiers in plant science · 2025Review
- Companion basil plants prime the tomato wound response through volatile signaling in a mixed planting system.Plant cell reports · 2024Article
- Comprehensive analysis of MAPK gene family in upland cotton (Gossypium hirsutum) and functional characterization of GhMPK31 in regulating defense response to insect infestation.Plant cell reports · 2024Article
- Chemically Mediated Plant-Plant Interactions: Allelopathy and Allelobiosis.Plants (Basel, Switzerland) · 2024Review
- Multi-omics analysis ofFrontiers in plant science · 2024Article
- Identification and expression analysis of MAPK cascade gene family in foxtail millet (Plant signaling & behavior · 2023Article
- Comparative Transcriptome Analysis of Defense Response of Potato toPlants (Basel, Switzerland) · 2023Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2023Article
- ExamPle: explainable deep learning framework for the prediction of plant small secreted peptides.Bioinformatics (Oxford, England) · 2023Article
- Dynamic distress calls: volatile info chemicals induce and regulate defense responses during herbivory.Frontiers in plant science · 2023Review
- Silencing ofPlant signaling & behavior · 2022Article
- Utilizing Proteomic Approach to Analyze Potential Antioxidant Proteins in Plant against Irradiation.Antioxidants (Basel, Switzerland) · 2022Article
50 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Systemin is a wound-signaling peptide that mediates defenses of tomato plants against herbivorous insects. Perception of systemin by the membrane-bound receptor SR160 results in activation of MAPKs, synthesis of jasmonic acid (JA), and expression of defense genes. To test the function of MAPKs in the response to systemin, we used virus-induced gene silencing (VIGS) in plants that overexpress the systemin precursor prosystemin (35S::prosys plants). These transgenic plants accumulate high levels of defense proteins and exhibit increased resistance to herbivorous insects. Cosilencing of the MAPKs MPK1 and MPK2 reduced MPK1/2 kinase activity, JA biosynthesis, and expression of JA-dependent defense genes. Application of methyl-JA restored the full defense response. These data show that MPK1 and MPK2 are essential components of the systemin signaling pathway and most likely function upstream of JA biosynthesis. MPK1 and MPK2 are 95% identical at the amino acid level. Specific VIGS of only MPK1 or MPK2 resulted in the same reduction of defense gene expression as cosilencing of MPK1 and MPK2, indicating that gene dosage effects may be important for MPK signaling. In addition, VIGS of the closely related MPK3 also reduced systemin-induced defense responses. The function of MPK1/2 and orthologs in pathogen-induced defenses is well established. Here we show that cosilencing of MPK1 and MPK2 compromised prosystemin-mediated resistance to Manduca sexta (Lepidoptera) herbivory, demonstrating that MPK1 and MPK2 are also required for successful defenses against herbivorous insects.
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