ArticleBehavioral and brain functions : BBF2007
Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD.
Article in Behavioral and brain functions : BBF, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 22 citations in OpenAlex.
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- Predicting Key Genes and Therapeutic Molecular Modelling to Explain the Association betweenInternational journal of molecular sciences · 2023Article
- Increased arterial pressure in mice with overexpression of the ADHD candidate gene calcyon in forebrain.PloS one · 2019Article
- Stress and corticosterone alter synaptic plasticity in a rat model of Parkinson's disease.Neuroscience letters · 2017Article
- The related neuronal endosomal proteins NEEP21 (Nsg1) and P19 (Nsg2) have divergent expression profiles in vivo.The Journal of comparative neurology · 2017Article
- Sex-dependent changes in ADHD-like behaviors in juvenile rats following cortical dopamine depletion.Behavioural brain research · 2014Article
- Calcyon forms a novel ternary complex with dopamine D1 receptor through PSD-95 protein and plays a role in dopamine receptor internalization.The Journal of biological chemistry · 2012Article
- The developmental impact of prenatal stress, prenatal dexamethasone and postnatal social stress on physiology, behaviour and neuroanatomy of primate offspring: studies in rhesus macaque and common marmoset.Psychopharmacology · 2011Review
- Deficits in fine motor skills in a genetic animal model of ADHD.Behavioral and brain functions : BBF · 2010Article
- Effects of antenatal dexamethasone treatment on glucocorticoid receptor and calcyon gene expression in the prefrontal cortex of neonatal and adult common marmoset monkeys.Behavioral and brain functions : BBF · 2010Article
- The spontaneously hypertensive rat model of ADHD--the importance of selecting the appropriate reference strain.Neuropharmacology · 2009Review
- A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice.Behavioural brain research · 2008Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcyon is a single transmembrane protein predominantly expressed in the brain. Very recently, calcyon has been implicated in clathrin mediated endocytosis, a critical component of synaptic plasticity. At the genetic level, preliminary evidence supports an association between attention-deficit/hyperactivity disorder (ADHD) and polymorphisms in the calcyon gene. As little is known about the potential role of calcyon in ADHD, animal models may provide important insights into this issue.
methodsWe examined calcyon mRNA expression in the frontal-striatal circuitry of three-, five-, and ten-week-old Spontaneously Hypertensive Rats (SHR), the most commonly used animal model of ADHD, and Wistar-Kyoto (WKY; the strain from which SHR were derived). As a complement, we performed a co-expression network analysis using a database of mRNA gene expression profiles of multiple brain regions in order to explore potential functional links of calcyon to other genes.
resultsIn all age groups, SHR expressed significantly more calcyon mRNA in the medial prefrontal and orbital frontal cortices than WKY rats. In contrast, in the motor cortex, dorsal striatum and nucleus accumbens, calcyon mRNA expression was only significantly elevated in SHR in younger animals. In both strains, calcyon mRNA levels decreased significantly with age in all regions studied. In the co-expression network analysis, we found a cluster of genes (many of them poorly studied so far) strongly connected to calcyon, which may help elucidate its role in the brain. The pair-wise relations of calcyon with other genes support its involvement in clathrin mediated endocytosis and, potentially, some other membrane/vesicular processes. Interestingly, no link was found between calcyon and the dopamine D1 receptor, which was previously shown to interact with the C-terminal of calcyon.
conclusionThe results indicate an alteration in calcyon expression within the frontal-striatal circuitry of SHR, especially in areas involved in cognitive processes. These findings extend our understanding of the molecular alterations in SHR, a heuristically useful model of ADHD.
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