Evidence map›Paper›PMID 17622543›Full record

ArticleInternational journal of colorectal disease2007

The sentinel node procedure in colon carcinoma: a multi-centre study in The Netherlands.

Wendy Kelder, Andries E Braat, Arend Karrenbeld, Joris A K Grond, Johannes E De Vries, J Wolter A Oosterhuis, Peter C Baas, John T M Plukker

Open access · hybridAbstract readEvaluation StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of colorectal disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. The Value of Sentinel Lymph Node Mapping for the Staging of Node-Negative Colon Cancer: Propensity Score and Mediation Analyses.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2021
    Article
  18. Review
  19. Sentinel Lymph Node Detection in Colorectal Cancer - First Experience.Open access Macedonian journal of medical sciences · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wendy KelderDepartment of Surgery, Martini Hospital, Groningen, The Netherlands.
Andries E BraatDepartment of Surgery, Isala Klinieken, Zwolle, The Netherlands.
Arend KarrenbeldDepartment of Pathology, University Medical Centre, Groningen, The Netherlands.
Joris A K GrondDepartment of Pathology, Laboratory of Public Health, Leeuwarden, The Netherlands.
Johannes E De VriesDepartment of Surgery, Isala Klinieken, Zwolle, The Netherlands.
J Wolter A OosterhuisDepartment of Surgery, Isala Klinieken, Zwolle, The Netherlands.
Peter C BaasDepartment of Surgery, Martini Hospital, Groningen, The Netherlands.
John T M PlukkerDepartment of Surgery, University Medical Centre Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands. j.t.m.plukker@chir.umcg.nl.
Isala · NLMartini Ziekenhuis · NLLeiden University · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymph node status is the most important predictive factor in colorectal carcinoma. Recurrences occur in 20% of the patients without lymph node metastases. The sentinel lymph node (SLN) biopsy is a tool to facilitate identification of micrometastatic disease and aberrant lymphatic drainage. We studied the feasibility of in vivo SLN detection in a multi-centre setting and evaluated nodal micro-staging using immunohistochemistry (IHC). MATERIALS AND

methodsSub-serosal injection with Patent Blue dye was used in the SLN procedure in 69 patients operated for localized colon cancer in six Dutch hospitals. Each SLN was examined with routine haematoxylin-eosin staining. In tumour-negative SLNs, we performed CK7/8 or 18 IHC.

resultsThe procedure was successful in 67 of 69 patients (97%). The SLN was negative in 43 patients. In three cases, it was false negative, resulting in a negative predictive value of 93% and an accuracy of 96%. In 24 of 27 patients with lymph node metastases in a successful SLN procedure, the SLN was positive (sensitivity 89%). In 15 patients, the SLN was the only positive node (21%). In nine patients, we only found micrometastases or isolated tumour cells, resulting in 18% upstaging. Aberrant lymphatic drainage was seen in three patients (4%).

conclusionThe SLN procedure in localized colon carcinoma is reliable in a multi-centre setting. It is helpful to identify patients who would be classified as stage II with conventional staging (18%) and who might benefit from adjuvant treatment.

Indexed as

Coloring AgentsRosaniline DyesSentinel Lymph Node BiopsyColonic NeoplasmsFalse Negative ReactionsFeasibility StudiesHumansImmunohistochemistryKeratin-18Keratin-7Keratin-8Lymphatic MetastasisLymph NodesNeoplasm StagingNetherlandsPredictive Value of TestsColoring AgentsKeratin-18Keratin-7Keratin-8KRT18 protein, humanKRT7 protein, humanKRT8 protein, humanRosaniline Dyessulfan blue

Identifiers

PMID17622543
PMCPMC2039795
OpenAlexW2133085434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.