ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2007
Locally applied simvastatin promotes fracture healing in ovariectomized rat.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Pleiotropic effects of statins on the treatment of chronic periodontitis--a systematic review.British journal of clinical pharmacology · 2015Pooled it
- The Effects of Statins on Bone Formation Around Implants Placed in Animal Bones: A Systematic Review and Meta-Analysis.Journal of maxillofacial and oral surgery · 2023Review
- Article
- Contribution of Statins towards Periodontal Treatment: A Review.Mediators of inflammation · 2019Review
- Simvastatin-doped pre-mixed calcium phosphate cement inhibits osteoclast differentiation and resorption.Journal of materials science. Materials in medicine · 2016Article
- Combination of simvastatin, calcium silicate/gypsum, and gelatin and bone regeneration in rabbit calvarial defects.Scientific reports · 2016Article
- A single CT-guided percutaneous intraosseous injection of thermosensitive simvastatin/poloxamer 407 hydrogel enhances vertebral bone formation in ovariectomized minipigs.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Metabolic and structural bone disturbances induced by hyperlipidic diet in mice treated with simvastatin.International journal of experimental pathology · 2015Article
- Single-dose local simvastatin injection improves implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system.International journal of nanomedicine · 2015Article
- Local injection of a single dose of simvastatin augments osteoporotic bone mass in ovariectomized rats.Journal of bone and mineral metabolism · 2014Article
- Platelet-rich plasma, plasma rich in growth factors and simvastatin in the regeneration and repair of alveolar bone.Experimental and therapeutic medicine · 2013Article
- Local delivery of controlled-release simvastatin/PLGA/HAp microspheres enhances bone repair.International journal of nanomedicine · 2013Article
- Mechanisms of bone anabolism regulated by statins.Bioscience reports · 2012Review
- Influence of statins locally applied from orthopedic implants on osseous integration.BMC musculoskeletal disorders · 2012Article
- Salubrinal promotes healing of surgical wounds in rat femurs.Journal of bone and mineral metabolism · 2012Article
- The effects of combined human parathyroid hormone (1-34) and zoledronic acid treatment on fracture healing in osteoporotic rats.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Article
- The pleiotropic effects of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in rheumatologic disorders: a comprehensive review.Rheumatology international · 2012Review
- Locally administrated perindopril improves healing in an ovariectomized rat tibial osteotomy model.PloS one · 2012Article
- Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/β-catenin signaling.Molecules and cells · 2011Article
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4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledSimvastatin solution was injected subcutaneously to the site of fractured tibiae of ovariectomized rats. Afterwards healing quality was evaluated by morphologic, radiographic, biomechanical, histological and histomorphometric methods at 1, 2 and 4 weeks after fracture. Results showed that locally applied simvastatin improved fracture healing.
introductionMany studies have documented an anabolic effect of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, on undisturbed bone. Reports of their effects, however, on fractured skeletal systems have been limited. A study was, therefore, conducted to check the effects of statins on fracture healing.
methodsSimvastatin (10 mg/kg/day) was injected subcutaneously to tissue overlying the site of fractured tibiae of ovariectomized rats for a treatment period of 5 days. Vehicle reagent was used as a control. Healing quality was evaluated at 1, 2 and 4 weeks after fracture.
resultsCompared with that in the vehicle group, the callus cross-section area in simvastatin-treated rats was significantly enlarged by 21.3% (p < 0.05) at 1 week and by 21.5% (p < 0.05) at 2 weeks; new woven bone was relatively substantive and arranged more tightly and regularly at 2 and 4 weeks; and maximal load was increased by 57.5% (p < 0.05) at 2 weeks and by 31.4% (p < 0.05) at 4 weeks. Histomorphometrically, simvastatin was associated with a significant (p < 0.05) increase of mineralization width (MLW), mineralization volume (MLV) and mineral apposition rate (MAR).
conclusionThe current study suggests that local application of simvastatin could promote fracture healing in ovariectomized rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.