ArticlePloS one2007
Molecular evolution and functional divergence of the Ca(2+) sensor protein in store-operated Ca(2+) entry: stromal interaction molecule.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Zinc binding to a conserved motif in STIM1 induces clustering and SOCE activation.Cell communication and signaling : CCS · 2025Article
- A Deep Dive into the N-Terminus of STIM Proteins: Structure-Function Analysis and Evolutionary Significance of the Functional Domains.Biomolecules · 2024Review
- Essential role of N-terminal SAM regions in STIM1 multimerization and function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- ORAI3 is dispensable for store-operated Ca2+ entry and immune responses by lymphocytes and macrophages.The Journal of general physiology · 2022Article
- Oocyte activation deficiency and assisted oocyte activation: mechanisms, obstacles and prospects for clinical application.Human reproduction open · 2022Review
- Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry.Scientific reports · 2020Article
- Article
- Structural Mechanisms of Store-Operated and Mitochondrial Calcium Regulation: Initiation Points for Drug Discovery.International journal of molecular sciences · 2020Review
- The 2β Splice Variation Alters the Structure and Function of the Stromal Interaction Molecule Coiled-Coil Domains.International journal of molecular sciences · 2018Article
- Role of STIM2 in cell function and physiopathology.The Journal of physiology · 2017Review
- Molecular mechanisms of STIM/Orai communication.American journal of physiology. Cell physiology · 2016Review
- Store-Operated Calcium Channels.Physiological reviews · 2015Review
- Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS.Nature communications · 2015Article
- Insights into the early evolution of animal calcium signaling machinery: a unicellular point of view.Cell calcium · 2015Review
- Oligomerization and Ca2+/calmodulin control binding of the ER Ca2+-sensors STIM1 and STIM2 to plasma membrane lipids.Bioscience reports · 2013Article
- Unraveling STIM2 function.Journal of physiology and biochemistry · 2012Review
- Calcium signaling in mammalian egg activation and embryo development: the influence of subcellular localization.Molecular reproduction and development · 2012Review
- A study of store dependent Ca²⁺ influx in frog skeletal muscle.Journal of muscle research and cell motility · 2012Article
- Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems.Trends in cell biology · 2011Review
- STIM proteins: integrators of signalling pathways in development, differentiation and disease.Journal of cellular and molecular medicine · 2010Review
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1 author.
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Abstract
Receptor-mediated Ca(2+) signaling in many non-excitable cells initially induces Ca(2+) release from intracellular Ca(2+) stores, followed by Ca(2+) influx across the plasma membrane. Recent findings have suggested that stromal interaction molecules (STIMs) function as the Ca(2+) sensor to detect changes of Ca(2+) content in the intracellular Ca(2+) stores. Human STIMs and invertebrate STIM share several functionally important protein domains, but diverge significantly in the C-terminus. To better understand the evolutionary significance of STIM activity, phylogenetic analysis of the STIM protein family was conducted after extensive database searching. Results from phylogeny and sequence analysis revealed early adaptation of the C-terminal divergent domains in Urochordata, before the expansion of STIMs in Vertebrata. STIMs were subsequently subjected to one round of gene duplication as early as in the Euteleostomi lineage in vertebrates, with a second round of fish-specific gene duplication. After duplication, STIM-1 and STIM-2 molecules appeared to have undergone purifying selection indicating strong evolutionary constraints within each group. Furthermore, sequence analysis of the EF-hand Ca(2+) binding domain and the SAM domain, together with functional divergence studies, identified critical regions/residues likely underlying functional changes, and provided evidence for the hypothesis that STIM-1 and STIM-2 might have developed distinct functional properties after duplication.
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