ArticlePloS one2007
Robustness and stability of the gene regulatory network involved in DV boundary formation in the Drosophila wing.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Frizzled2 receives WntA signaling during butterfly wing pattern formation.Development (Cambridge, England) · 2023Article
- Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models.Frontiers in physiology · 2020Review
- Cux2 refines the forelimb field by controlling expression ofBiology open · 2019Article
- Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna.PLoS genetics · 2017Article
- Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia.PLoS computational biology · 2017Article
- Wnt-Notch signalling crosstalk in development and disease.Cellular and molecular life sciences : CMLS · 2014Review
- Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis.Development (Cambridge, England) · 2014Article
- Article
- Dynamics and mechanical stability of the developing dorsoventral organizer of the wing imaginal disc.PLoS computational biology · 2011Article
- The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.PloS one · 2010Article
- Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells.Developmental biology · 2010Article
- A spatial toggle switch drives boundary formation in development.Biophysical journal · 2008Article
- A Wingless and Notch double-repression mechanism regulates G1-S transition in the Drosophila wing.The EMBO journal · 2008Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene regulatory networks have been conserved during evolution. The Drosophila wing and the vertebrate hindbrain share the gene network involved in the establishment of the boundary between dorsal and ventral compartments in the wing and adjacent rhombomeres in the hindbrain. A positive feedback-loop between boundary and non-boundary cells and mediated by the activities of Notch and Wingless/Wnt-1 leads to the establishment of a Notch dependent organizer at the boundary. By means of a Systems Biology approach that combines mathematical modeling and both in silico and in vivo experiments in the Drosophila wing primordium, we modeled and tested this regulatory network and present evidence that a novel property, namely refractoriness to the Wingless signaling molecule, is required in boundary cells for the formation of a stable dorsal-ventral boundary. This new property has been validated in vivo, promotes mutually exclusive domains of Notch and Wingless activities and confers stability to the dorsal-ventral boundary. A robustness analysis of the regulatory network complements our results and ensures its biological plausibility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.