ArticlePloS one2007
Genetic variation for cardiac dysfunction in Drosophila.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- trithorax is an essential regulator of cardiac Hox gene expression and anterior-posterior patterning of the Drosophila embryonic heart tube.Biology open · 2025Article
- Dual color optogenetic tool enables heart arrest, bradycardic, and tachycardic pacing in Drosophila melanogaster.Communications biology · 2024Article
- Article
- Conservation of cardiac L-type CaJournal of molecular and cellular cardiology · 2018Article
- Expanded CCUG repeat RNA expression in Drosophila heart and muscle trigger Myotonic Dystrophy type 1-like phenotypes and activate autophagocytosis genes.Scientific reports · 2017Article
- Animal and in silico models for the study of sarcomeric cardiomyopathies.Cardiovascular research · 2015Review
- Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.Genetics · 2014Article
- Sestrins orchestrate cellular metabolism to attenuate aging.Cell metabolism · 2013Review
- The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster.PLoS genetics · 2013Article
- Complex genetic architecture of cardiac disease in a wild type inbred strain of Drosophila melanogaster.PloS one · 2013Article
- Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities.The Journal of biological chemistry · 2011Article
- Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery.Pharmacological reviews · 2011Review
- Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila.Genes & development · 2011Article
- High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.Cell metabolism · 2010Article
- Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila.PLoS genetics · 2010Article
- Monitoring heart function in larval Drosophila melanogaster for physiological studies.Journal of visualized experiments : JoVE · 2009Article
- Serial examination of an inducible and reversible dilated cardiomyopathy in individual adult Drosophila.PloS one · 2009Article
- Non-autonomous modulation of heart rhythm, contractility and morphology in adult fruit flies.Developmental biology · 2009Article
- Modifier effects between regulatory and protein-coding variation.PLoS genetics · 2008Article
- Drosophila melanogaster as a model system for genetics of postnatal cardiac function.Drug discovery today. Disease models · 2008Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommon diseases may be attributed to combinations of variant alleles, but there are few model systems where the interactions among such variants can be studied in controlled genetic crosses. While association studies are designed to detect common polymorphisms of moderate effect, new approaches are required to characterize the impact on disease of interactions among rare alleles. METHODOLOGY/PRINCIPAL
findingsWe show that wild populations of Drosophila melanogaster harbor rare polymorphisms of major effect (RAME) that predispose flies to a specific disease phenotype, age-dependent cardiac dysfunction. A screen of fifty inbred wild-type lines revealed a continuous spectrum of pacing-induced heart failure that generally increases in frequency with age. High-speed video analysis of the inbred lines with high rates of inducible heart failure indicates specific defects in cardiac function, including arrhythmias and contractile disorders ('cardiomyopathies'). A combination of bulked segregant analysis and single feature polymorphism (SFP) detection localizes one of the cardiac susceptibility loci to the 97C interval on the fly genome. CONCLUSIONS/SIGNIFICANCE: Wild-type Drosophila, like humans, are predisposed to cardiac dysfunction. Identification of factors associated with these naturally occurring cardiac traits promises to provide important insights into the epidemiology of cardiac disease.
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