ArticleMolecular medicine (Cambridge, Mass.)
Transcription factors in muscle atrophy caused by blocked neuromuscular transmission and muscle unloading in rats.
Article in Molecular medicine (Cambridge, Mass.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Chaperone co-inducer BGP-15 mitigates early contractile dysfunction of the soleus muscle in a rat ICU model.Acta physiologica (Oxford, England) · 2020Article
- The Effects of Calcium-Oxidative medicine and cellular longevity · 2020Article
- Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model.Acta physiologica (Oxford, England) · 2019Article
- Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy.Journal of muscle research and cell motility · 2015Review
- The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.Physiological reviews · 2015Review
- Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.American journal of physiology. Endocrinology and metabolism · 2014Review
- Masseter muscle myofibrillar protein synthesis and degradation in an experimental critical illness myopathy model.PloS one · 2014Article
- The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle.Frontiers in aging neuroscience · 2014Review
- Sparing of muscle mass and function by passive loading in an experimental intensive care unit model.The Journal of physiology · 2013Article
- Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading.Critical care (London, England) · 2012Article
- Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms.The Journal of physiology · 2011Article
- The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy.Pflugers Archiv : European journal of physiology · 2011Review
- Article
- The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism?European journal of applied physiology · 2010Review
- Myofibrillar protein and gene expression in acute quadriplegic myopathy.Journal of the neurological sciences · 2009Article
- Myotube formation on micro-patterned glass: intracellular organization and protein distribution in C2C12 skeletal muscle cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The muscle wasting associated with long-term intensive care unit (ICU) treatment has a negative effect on muscle function resulting in prolonged periods of rehabilitation and a decreased quality of life. To identify mechanisms behind this form of muscle wasting, we have used a rat model designed to mimic the conditions in an ICU. Rats were pharmacologically paralyzed with a postsynaptic blocker of neuromuscular transmission, and mechanically ventilated for one to two weeks, thereby unloading the limb muscles. Transcription factors were analyzed for cellular localization and nuclear concentration in the fast-twitch muscle extensor digitorum longus (EDL) and in the slow-twitch soleus. Significant muscle wasting and upregulation of mRNA for the ubiquitin ligases MAFbx and MuRF1 followed the treatment. The IkappaB family-member Bcl-3 displayed a concomitant decrease in concentration, suggesting altered kappaB controlled gene expression, although NFkappaB p65 was not significantly affected. The nuclear levels of the glucocorticoid receptor (GR) and the thyroid receptor alpha1 (TRalpha1) were altered and also suggested as potential mediators of the MAFbx- and MuRF1-induction in the absence of induced Foxo1. We believe that this model, and the strategy of quantifying nuclear proteins, will provide a valuable tool for further, more detailed, analyses of the muscle wasting occurring in patients kept on a mechanical ventilator.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.