Trial reportEuropean journal of clinical nutrition2008
Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study.
Trial report in European journal of clinical nutrition, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07367412 (Effect of Zinc Supplementation on Occurrence of Infections in Older Medical Patients), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Zinc Supplementation on Occurrence of Infections in Older Medical Patients (ZOOM) - a Cluster Randomized Controlled Trial (ZOOM OUT).
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Zinc supplements for preventing otitis media.The Cochrane database of systematic reviews · 2014Pooled it
- Antioxidant effect of zinc supplementation on both plasma and cellular red-ox status markers in a group of elderly Italian population.The journal of nutrition, health & aging · 2014Trial
- Nutritional Interventions for Elderly and Considerations for the Development of Geriatric Foods.Current aging science · 2019Review
- Biomarkers of Nutrition for Development (BOND)-Zinc Review.The Journal of nutrition · 2015Article
- Zinc: dietary intake and impact of supplementation on immune function in elderly.Age (Dordrecht, Netherlands) · 2013Review
- Both human immunodeficiency virus-infected and human immunodeficiency virus-exposed, uninfected children living in Brazil, Argentina, and Mexico have similar rates of low concentrations of retinol, beta-carotene, and vitamin E.Nutrition research (New York, N.Y.) · 2009Article
- Clinical Significance of Serum Zinc Levels on the Development of Sarcopenia in Cirrhotic Patients.Cancer diagnosis & prognosisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the effects of zinc supplementation on vitamin status in middle-aged and older volunteers. SUBJECTS/
methodsThree hundred and eighty-seven healthy middle-aged (55-70 years) and older (70-85 years) men and women, randomly allocated to three groups to receive 15 or 30 mg Zn/day or placebo for 6 months. Dietary intake was assessed by means of a validated 4-day recall record. Fasting blood samples were simultaneously analysed for levels of plasma retinol and alpha-tocopherol by high-performance liquid chromatography. Erythrocyte folates were measured by a competitive immunoassay with direct chemiluminescence detection on an automatized immunoanalyser. Biochemical measurements were performed at baseline and after 3 and 6 months of zinc supplementation.
resultsPlasma vitamin A levels were significantly increased proportionally with zinc dose and period of treatment, particularly at 6 months (for 15 mg Zn/day, P<0.05; for 30 mg Zn/day, P<0.0001); no significant changes were observed in the placebo group. There was no effect of zinc supplementation on vitamin E/cholesterol ratio and erythrocyte folates.
conclusionsOur results show that a long-term zinc supplementation increases plasma vitamin A levels in middle-aged and older people of similar characteristics to those involved in this study. Moreover, supplementation influences serum zinc levels but does not affect erythrocyte zinc concentration and both plasma vitamin E and erythrocyte folate status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.