ArticlePLoS biology2007
A dendrite-autonomous mechanism for direction selectivity in retinal starburst amacrine cells.
Article in PLoS biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 158 citations in OpenAlex.
- Retinal waves shape starburst amacrine cell dendrite development through a direction-selective dendritic computation.Cell reports · 2026Article
- Unraveling the role of asymmetric excitatory and inhibitory synaptic inputs to retinal ganglion cell direction selectivity.Frontiers in neuroscience · 2026Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Overcoming the limitations of motion sensor models by considering dendritic computations.Scientific reports · 2025Article
- Optimization in Visual Motion Estimation.Annual review of vision science · 2024Review
- Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells.Nature communications · 2024Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.eLife · 2023Article
- Direct comparison reveals algorithmic similarities in fly and mouse visual motion detection.iScience · 2023Article
- Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.bioRxiv : the preprint server for biology · 2023Article
- Two mechanisms for direction selectivity in a model of the primate starburst amacrine cell.Visual neuroscience · 2023Article
- Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina.Frontiers in cellular neuroscience · 2023Article
- Presynaptic depolarization differentially regulates dual neurotransmitter release from starburst amacrine cells in the mouse retina.Frontiers in ophthalmology · 2023Article
- GABAAR-mediated tonic inhibition differentially modulates intrinsic excitability of VIP- and SST- expressing interneurons in layers 2/3 of the somatosensory cortex.Frontiers in cellular neuroscience · 2023Article
- Article
- Center-surround interactions underlie bipolar cell motion sensitivity in the mouse retina.Nature communications · 2022Article
- Classical center-surround receptive fields facilitate novel object detection in retinal bipolar cells.Nature communications · 2022Article
- Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy.Cell · 2022Article
- Origins of direction selectivity in the primate retina.Nature communications · 2022Article
- Gain control by sparse, ultra-slow glycinergic synapses.Cell reports · 2022Article
- Cholinergic feedback to bipolar cells contributes to motion detection in the mouse retina.Cell reports · 2021Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Detection of image motion direction begins in the retina, with starburst amacrine cells (SACs) playing a major role. SACs generate larger dendritic Ca(2+) signals when motion is from their somata towards their dendritic tips than for motion in the opposite direction. To study the mechanisms underlying the computation of direction selectivity (DS) in SAC dendrites, electrical responses to expanding and contracting circular wave visual stimuli were measured via somatic whole-cell recordings and quantified using Fourier analysis. Fundamental and, especially, harmonic frequency components were larger for expanding stimuli. This DS persists in the presence of GABA and glycine receptor antagonists, suggesting that inhibitory network interactions are not essential. The presence of harmonics indicates nonlinearity, which, as the relationship between harmonic amplitudes and holding potential indicates, is likely due to the activation of voltage-gated channels. [Ca(2+)] changes in SAC dendrites evoked by voltage steps and monitored by two-photon microscopy suggest that the distal dendrite is tonically depolarized relative to the soma, due in part to resting currents mediated by tonic glutamatergic synaptic input, and that high-voltage-activated Ca(2+) channels are active at rest. Supported by compartmental modeling, we conclude that dendritic DS in SACs can be computed by the dendrites themselves, relying on voltage-gated channels and a dendritic voltage gradient, which provides the spatial asymmetry necessary for direction discrimination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.