ReviewSeminars in immunopathology2007
Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia.
Review in Seminars in immunopathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it, 200 citations in OpenAlex.
- Analysis of the evolution of placental oxidative stress research from a bibliometric perspective.Frontiers in pharmacology · 2024Pooled it
- Placental secretion of interleukin-1 and interleukin-1 receptor antagonist in preeclampsia: effect of magnesium sulfate.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2012Trial
- Maternal Inflammatory Biomarkers at 28 Weeks of Pregnancy and Childhood Adiposity at Age 7 and 13 Years in the Seychelles Child Development Study.Maternal and child health journal · 2026Article
- Administration of Natural Fish and Algal Oils in Nanoparticle Form to Pregnant Gilts and Newborn Piglets: Biochemical Effects and Spatial-Socio-Economic Implications for Regional Food Systems.International journal of molecular sciences · 2025Article
- Article
- Biomarkers of Inflammation and Their Association With the Severity and Onset of Preeclampsia: A Systematic Review.Cureus · 2025Review
- Leukocyte dynamics in female reproductive health: roles and mechanisms.Annals of medicine and surgery (2012) · 2025Review
- Metabolic theory of preeclampsia: implications for maternal cardiovascular health.American journal of physiology. Heart and circulatory physiology · 2024Review
- Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.American journal of obstetrics and gynecology · 2024Article
- MicroRNA-223-3p downregulates the inflammatory response in preeclampsia placenta via targeting NLRP3.BMC pregnancy and childbirth · 2024Article
- Immune checkpoint molecules B7-1 and B7-H1 as predictive markers of pre-eclampsia: A case-control study in a Ghana.Immunity, inflammation and disease · 2024Article
- Plasma Olink Proteomics Identifies CCL20 as a Novel Predictive and Diagnostic Inflammatory Marker for Preeclampsia.Journal of proteome research · 2022Article
- Maternal Blood-Based Protein Biomarkers in Relation to Abdominal Fat Distribution Measured by Ultrasound in Early Mid-Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- miR-218-5p Induces Interleukin-1β and Endovascular Trophoblast Differentiation by Targeting the Transforming Growth Factor β-SMAD2 Pathway.Frontiers in endocrinology · 2022Article
- Utero-Placental Immune Milieu during Normal and Aglepristone-Induced Parturition in the Dog.Animals : an open access journal from MDPI · 2021Article
- Cyclosporine A and Tacrolimus Induce Functional Impairment and Inflammatory Reactions in Endothelial Progenitor Cells.International journal of molecular sciences · 2021Article
- Autism spectrum disorders in extremely preterm infants and placental pathology findings: a matched case-control study.Pediatric research · 2021Article
- Cytokine Imprint in Preeclampsia.Frontiers in immunology · 2021Article
- Inflammatory cytokines, placental pathology, and neurological outcomes in infants born to preterm preeclamptic mothers.PloS one · 2021Article
- Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human pregnancy is a metabolic and immune challenge for the mother who has to accommodate in her womb a semi-allogeneic fetus whose energy needs increase tremendously with gestation. Recent compelling research has suggested that proper inflammatory changes and oxidative balance are a requisite for successful pregnancy. The placenta is an integral component of this inflammatory response as it actively produces a variety of cytokines and immunomodulatory hormones. In preeclampsia, a life-threatening disorder of pregnancy that is characterized by widespread damage and dysfunction of the maternal endothelium, placental oxidative stress and aberrant cytokine expression induces an exaggerated maternal systemic inflammatory response to pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.