ArticleProceedings of the National Academy of Sciences of the United States of America2007
A typology of photoreceptor gene expression patterns in the mouse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 98 citations in OpenAlex.
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- Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells.Gene therapy · 2021Article
- Analysis of Early Cone Dysfunction in an In Vivo Model of Rod-Cone Dystrophy.International journal of molecular sciences · 2020Article
- Modeling binary and graded cone cell fate patterning in the mouse retina.PLoS computational biology · 2020Article
- Enhancer transcription identifiesDevelopment (Cambridge, England) · 2020Article
- Using BXD mouse strains in vision research: A systems genetics approach.Molecular vision · 2020Review
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- A single-cell transcriptome atlas of the adult human retina.The EMBO journal · 2019Article
- Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.Developmental biology · 2019Article
- Non-coding RNAs in retinal development and function.Human genetics · 2019Review
- CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity.International journal of molecular sciences · 2019Article
- Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision.Scientific reports · 2019Article
- High-Throughput Analysis of Retinal Cis-Regulatory Networks by Massively Parallel Reporter Assays.Advances in experimental medicine and biology · 2019Review
- 661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.Frontiers in genetics · 2019Article
- Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors.Progress in retinal and eye research · 2018Review
- D-cis-Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo.Investigative ophthalmology & visual science · 2018Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Mutations in photoreceptor-enriched genes have been implicated in dozens of human retinal diseases, yet no systematic analysis of rod and cone gene expression patterns has been carried out. In addition, although cone photoreceptor loss accounts for much of the morbidity of retinal disease, relatively few cone-specific genes are known. In this study, we carried out microarray and in situ hybridization analyses of the mouse Neural retina leucine zipper gene (Nrl) mutant, which shows an en masse conversion of rods into cones, to establish a typology of photoreceptor gene expression and to identify novel cone-specific genes. We found a total of 18 new cone-enriched genes, some of which map near uncloned retinal disease loci. Several of these genes have a dorsal-ventral (D-V) pattern of expression similar to that of short- or medium-wavelength opsins. We carried out microarray analysis of dorsal and ventral microdissected WT retina and found additional photoreceptor genes with an asymmetric distribution. Overall, we found that photoreceptor genes fall on an expression spectrum from rod-specific to cone-specific, with many showing varying degrees of rod and cone coexpression. These expression patterns can be reliably predicted from microarray data alone. Our results demonstrate definitive molecular differences between rods and cones that may underlie the physiological differences between these two classes of photoreceptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.