ArticleInfection and immunity2007
Enterococcal leucine-rich repeat-containing protein involved in virulence and host inflammatory response.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- DUF916 and DUF3324 in the WxL protein cluster bind to WxL and link bacterial and host surfaces.Protein science : a publication of the Protein Society · 2023Article
- Prevalence ofPathogens (Basel, Switzerland) · 2023Article
- Bioinformatic analysis of WxL domain proteins.Saudi journal of biological sciences · 2023Article
- Comparative Genomic Analyses ofMicroorganisms · 2021Article
- Mycoplasma bovisJournal of bacteriology · 2020Article
- Molecular basis for the emergence of a new hospital endemic tigecycline-resistant Enterococcus faecalis ST103 lineage.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2019Article
- A Systematic Approach to Identify and Characterize the Effectiveness and Safety of Novel Probiotic Strains to Control Foodborne Pathogens.Frontiers in microbiology · 2019Article
- Prevalence of Aminoglycoside Resistance Genes in Enterococcus Strains in Kermanshah, Iran.Iranian journal of medical sciences · 2018Article
- Exploration of the role of the virulence factor ElrA during Enterococcus faecalis cell infection.Scientific reports · 2018Article
- Article
- Review
- The Enterococcus faecalis virulence factor ElrA interacts with the human Four-and-a-Half LIM Domains Protein 2.Scientific reports · 2017Article
- A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens againstFrontiers in microbiology · 2017Article
- Article
- Genome-based characterization of hospital-adaptedNature microbiology · 2016Article
- Whole genome sequencing revealed host adaptation-focused genomic plasticity of pathogenic Leptospira.Scientific reports · 2016Article
- Minimal genomes of mycoplasma-related endobacteria are plastic and contain host-derived genes for sustained life within Glomeromycota.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Overexpression of Enterococcus faecalis elr operon protects from phagocytosis.BMC microbiology · 2015Article
- The identification and functional characterization of WxL proteins from Enterococcus faecium reveal surface proteins involved in extracellular matrix interactions.Journal of bacteriology · 2015Article
- Enterococcal Rgg-like regulator ElrR activates expression of the elrA operon.Journal of bacteriology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterococcus faecalis is an important nosocomial pathogen associated with high morbidity and mortality for patients who are immunocompromised or who have severe underlying diseases. The E. faecalis genome encodes numerous surface-exposed proteins that may be involved in virulence. This work describes the characterization of the first internalin-like protein in E. faecalis, ElrA, belonging to the recently identified WxL family of surface proteins. ElrA contains an N-terminal signal peptide for export, a leucine-rich repeat domain that may interact with host cells, and a C-terminal WxL domain that interacts with the peptidoglycan. Disruption of the elrA gene significantly attenuates bacterial virulence in a mouse peritonitis model. The elrA deletion mutant also displays a defect in infection of host macrophages and a decreased interleukin-6 response in vivo. Finally, elrA expression is induced in vivo. Altogether, these results demonstrate a role for ElrA in the E. faecalis infectious process in vivo and suggest that this surface protein may contribute to E. faecalis virulence by stimulating the host inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.