ArticleRespiratory research2007
Peripheral infusion of rat bone marrow derived endothelial progenitor cells leads to homing in acute lung injury.
Article in Respiratory research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 109 citations in OpenAlex.
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- Cell Sheets of Co-cultured Endothelial Progenitor Cells and Mesenchymal Stromal Cells Promote Osseointegration in Irradiated Rat Bone.Scientific reports · 2017Article
- Transplantation of Menstrual Blood-Derived Mesenchymal Stem Cells Promotes the Repair of LPS-Induced Acute Lung Injury.International journal of molecular sciences · 2017Article
- 5-Aza-2'-deoxycytidine protects against emphysema in mice via suppressing p16International journal of chronic obstructive pulmonary disease · 2017Article
- Endothelial bioreactor system ameliorates multiple organ dysfunction in septic rats.Intensive care medicine experimental · 2016Article
- Low-dose irradiation prior to bone marrow transplantation results in ATM activation and increased lethality in Atm-deficient mice.Bone marrow transplantation · 2016Article
- Stem/progenitor cells in endogenous repairing responses: new toolbox for the treatment of acute lung injury.Journal of translational medicine · 2016Review
- Decitabine enhances stem cell antigen-1 expression in cigarette smoke extract-induced emphysema in animal model.Experimental biology and medicine (Maywood, N.J.) · 2016Article
- Effects of Vascular Endothelial Growth Factor in Recovery Phase of Acute Lung Injury in Mice.Lung · 2015Article
- Effects of Astragaloside IV on the SDF-1/CXCR4 Expression in Atherosclerosis of apoE(-/-) Mice Induced by Hyperlipaemia.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells.American journal of physiology. Heart and circulatory physiology · 2014Article
- Bone marrow-derived progenitor cells attenuate inflammation in lipopolysaccharide-induced acute respiratory distress syndrome.BMC research notes · 2014Article
- Time Dependence of Material Properties of Polyethylene Glycol Hydrogels Chain Extended with Short Hydroxy Acid Segments.Polymer · 2014Article
- Differential characteristics and in vitro angiogenesis of bone marrow- and peripheral blood-derived endothelial progenitor cells: evidence from avian species.Cell proliferation · 2014Article
- A novel early precursor cell population from rat bone marrow promotes angiogenesis in vitro.BMC cell biology · 2014Article
- Effect of lipopolysaccharide on the characteristics of endothelial progenitor cells from bone marrow in mice.Molecular medicine reports · 2014Article
- Stem cells, cell therapies, and bioengineering in lung biology and diseases. Comprehensive review of the recent literature 2010-2012.Annals of the American Thoracic Society · 2013Review
- Adult stem cells for acute lung injury: remaining questions and concerns.Respirology (Carlton, Vic.) · 2013Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone marrow-derived progenitors for both epithelial and endothelial cells have been observed in the lung. Besides mature endothelial cells (EC) that compose the adult vasculature, endothelial progenitor cells (EPC) are supposed to be released from the bone marrow into the peripheral blood after stimulation by distinct inflammatory injuries. Homing of ex vivo generated bone marrow-derived EPC into the injured lung has not been investigated so far. We therefore tested the hypothesis whether homing of EPC in damaged lung tissue occurs after intravenous administration.
methodsEx vivo generated, characterized and cultivated rat bone marrow-derived EPC were investigated for proliferation and vasculogenic properties in vitro. EPC were tested for their homing in a left-sided rat lung transplant model mimicking a severe acute lung injury. EPC were transplanted into the host animal by peripheral administration into the femoral vein (10(6) cells). Rats were sacrificed 1, 4 or 9 days after lung transplantation and homing of EPC was evaluated by fluorescence microscopy. EPC were tested further for their involvement in vasculogenesis processes occurring in subcutaneously applied Matrigel in transplanted animals.
resultsWe demonstrate the integration of intravenously injected EPC into the tissue of the transplanted left lung suffering from acute lung injury. EPC were localized in vessel walls as well as in destructed lung tissue. Virtually no cells were found in the right lung or in other organs. However, few EPC were found in subcutaneous Matrigel in transplanted rats.
conclusionTransplanted EPC may play an important role in reestablishing the endothelial integrity in vessels after severe injury or at inflammatory sites and might further contribute to vascular repair or wound healing processes in severely damaged tissue. Therapeutic applications of EPC transplantation may ensue.
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