ArticlePharmaceutical research2008
Effect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols.
Article in Pharmaceutical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Small scale electrostatically-driven aerosol deposition inFrontiers in physiology · 2025Article
- Studies of the Crystallization and Dissolution of Individual Suspended Sodium Chloride Aerosol Particles.The journal of physical chemistry. A · 2024Article
- Dextran Mass Ratio Controls Particle Drying Dynamics in a Thermally Stable Dry Powder Vaccine for Pulmonary Delivery.Pharmaceutical research · 2022Article
- Administration of dry powders during respiratory supports.Annals of translational medicine · 2021Review
- Fragmented particles containing octreotide acetate prepared by spray drying technique for dry powder inhalation.Drug delivery and translational research · 2018Article
- Effect of Relative Humidity on Bipolar Electrostatic Charge Profiles of dry Powder Aerosols.Pharmaceutical research · 2017Article
- Inhaler technique: facts and fantasies. A view from the Aerosol Drug Management Improvement Team (ADMIT).NPJ primary care respiratory medicine · 2016Review
- Effect of crystallinity on electrostatic charging in dry powder inhaler formulations.Pharmaceutical research · 2014Article
- Comparison of in vitro deposition of pharmaceutical aerosols in an idealized child throat with in vivo deposition in the upper respiratory tract of children.Pharmaceutical research · 2014Article
- The influence of actuator materials and nozzle designs on electrostatic charge of pressurised metered dose inhaler (pMDI) formulations.Pharmaceutical research · 2014Article
- The contribution of different formulation components on the aerosol charge in carrier-based dry powder inhaler systems.Pharmaceutical research · 2010Article
- Investigation of electrostatic behavior of a lactose carrier for dry powder inhalers.Pharmaceutical research · 2008Article
- Design of a device for simultaneous particle size and electrostatic charge measurement of inhalation drugs.Pharmaceutical research · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAt present, there is no published data examining the effect of relative humidity on the electrostatic charges of dry powder inhaler aerosols. The charging behaviour of two commercial products, Pulmicort and Bricanyl Turbuhalers, were investigated using an electrical low pressure impactor (ELPI).
methodsELPI was successfully modified to disperse the aerosols at 60 l/min. Four doses from each new inhaler were sampled at 15, 40, 65, and 90% RH. Particles deposited on the impactor stages according to their aerodynamic diameters and their charges were measured simultaneously by the electrometers. The drug in each size fraction was quantified using HPLC.
resultsBoth products generated bipolar charges. The charging behaviour of the two types of inhaler showed different humidity dependence although the mass output was not significantly affected. The absolute specific charge of budesonide fine particles from Pulmicort was the lowest at 40% RH but increased at lower and higher RHs. In contrast, the terbutaline sulfate fine particles from Bricanyl followed the expected trend of charge reduction with increasing RH.
conclusionsThe distinct trends of charging of aerosols from Pulmicort and Bricanyl Turbuhalers was explained by differences in hygroscopicity and other physicochemical factors between the two drugs.
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Registered trials
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