ArticleJournal of materials science. Materials in medicine2008
Bone tissue formation in sheep muscles induced by a biphasic calcium phosphate ceramic and fibrin glue composite.
Article in Journal of materials science. Materials in medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 82 citations in OpenAlex.
- Pyrophosphate-Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality.Advanced healthcare materials · 2025Article
- Engineering Precise Interconnected Porosity in β-Tricalcium Phosphate (β-TCP) Matrices by Means of Top-Down Digital Light Processing.Biomedicines · 2024Article
- Effect of a synthetic hydroxyapatite-based bone grafting material compared to established bone substitute materials on regeneration of critical-size bone defects in the ovine scapula.Regenerative biomaterials · 2024Article
- Application of Dental Pulp Stem Cells for Bone and Neural Tissue Regeneration in Oral and Maxillofacial Region.Stem cells international · 2023Review
- Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone.Bioengineering (Basel, Switzerland) · 2022Review
- Costimulatory Effect of Rough Calcium Phosphate Coating and Blood Mononuclear Cells on Adipose-Derived Mesenchymal Stem Cells In Vitro as a Model of In Vivo Tissue Repair.Materials (Basel, Switzerland) · 2020Article
- In Vitro and In Vivo Biocompatibility Studies of a Cast and Coated Titanium Alloy.Molecules (Basel, Switzerland) · 2020Article
- Fibrin biopolymer as scaffold candidate to treat bone defects in rats.The journal of venomous animals and toxins including tropical diseases · 2019Article
- Article
- The material and biological characteristics of osteoinductive calcium phosphate ceramics.Regenerative biomaterials · 2018Review
- Article
- Enhanced Osteogenic and Vasculogenic Differentiation Potential of Human Adipose Stem Cells on Biphasic Calcium Phosphate Scaffolds in Fibrin Gels.Stem cells international · 2016Article
- Porous biphasic calcium phosphate ceramics coated with nano-hydroxyapatite and seeded with mesenchymal stem cells for reconstruction of radius segmental defects in rabbits.Journal of materials science. Materials in medicine · 2015Article
- Biomaterials for Bone Regenerative Engineering.Advanced healthcare materials · 2015Review
- An overview of recent advances in designing orthopedic and craniofacial implants.Journal of biomedical materials research. Part A · 2013Review
- Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study.Journal of periodontal & implant science · 2012Article
- Improvement of osteogenic potential of biphasic calcium phosphate bone substitute coated with two concentrations of expressed recombinant human bone morphogenetic protein 2.Journal of periodontal & implant science · 2012Article
- Brief review of models of ectopic bone formation.Stem cells and development · 2012Review
- The use of calcium phosphate-based biomaterials in implant dentistry.Journal of materials science. Materials in medicine · 2012Article
- Healing of acute alveolar bone dehiscence following treatment with porous biphasic calcium phosphate in beagle dogs.Clinical oral investigations · 2011Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some biomaterials are able to induce ectopic bone formation in muscles of large animals. The osteoinductive potential of macro- micro-porous biphasic calcium phosphate (MBCP) ceramic granules with fibrin glue was evaluated by intramuscular implantation for 6 months in six adult female sheep. The MBCP granules were 1-2 mm in size and were composed of hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) in a 60/40 ratio. The fibrin glue was composed of fibrinogen, thrombin and other biological factors. After 6 months of implantation in the dorsal muscles of sheep, the explants were rigid. Histology, back-scattered electron microscopy and micro-computed tomography of the implants indicated that approximately 12% of mineralized bone had formed in between the MBCP granules. The ectopic bone appeared well-mineralized with mature osteocytes and Haversian structures. In addition, the number and thickness of bone trabeculae formed in between the MBCP particles were similar to those measured in trabecular bone in sheep. The overall results therefore confirmed the formation of well-mineralized ectopic bone tissue after intramuscular implantation of MBCP/fibrin glue composites. These bone substitutes exhibiting osteoinductive properties could be used for the reconstruction of large bone defects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.