ReviewWorld journal of urology2007
Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases.
Review in World journal of urology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Neutrophil extracellular traps involved in the pathogenesis of IgA vasculitis: Confirmed in two IgAV rat models.PloS one · 2023Article
- IgA Staining Patterns Differentiate Between IgA Nephropathy and IgA-Dominant Infection-Associated Glomerulonephritis.Kidney international reports · 2020Article
- Urine Proteomic Study in OAB Patients-Preliminary Report.Journal of clinical medicine · 2020Article
- Urinary proteomics of Henoch-Schönlein purpura nephritis in children using liquid chromatography-tandem mass spectrometry.Clinical proteomics · 2020Article
- Noninvasive Urinary Monitoring of Progression in IgA Nephropathy.International journal of molecular sciences · 2019Article
- Candidate Urine Peptide Biomarkers for IgA Nephropathy: Where Are We Now?Disease markers · 2018Review
- Noninvasive diagnosis of chronic kidney diseases using urinary proteome analysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis.Molecular medicine reports · 2017Article
- Urinary myeloid IgA Fc alpha receptor (CD89) and transglutaminase-2 as new biomarkers for active IgA nephropathy and henoch-Schönlein purpura nephritis.BBA clinical · 2016Article
- Mini-review: emerging roles of microRNAs in the pathophysiology of renal diseases.American journal of physiology. Renal physiology · 2016Review
- Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria.Clinical proteomics · 2015Article
- Human Urine Proteomics: Analytical Techniques and Clinical Applications in Renal Diseases.International journal of proteomics · 2015Review
- Urine proteomes of healthy aging humans reveal extracellular matrix (ECM) alterations and immune system dysfunction.Age (Dordrecht, Netherlands) · 2014Article
- Significance of urinary proteome pattern in renal allograft recipients.Journal of transplantation · 2014Review
- Biomarkers in IgA nephropathy: relationship to pathogenetic hits.Expert opinion on medical diagnostics · 2013Review
- Association of urinary laminin G-like 3 and free K light chains with disease activity and histological injury in IgA nephropathy.Clinical journal of the American Society of Nephrology : CJASN · 2013Article
- Poor histological lesions in IgA nephropathy may be reflected in blood and urine peptide profiling.BMC nephrology · 2013Article
- Urine proteome of autosomal dominant polycystic kidney disease patients.Clinical proteomics · 2012Article
- Urinary mannose-binding lectin is a biomarker for predicting the progression of immunoglobulin (Ig)A nephropathy.Clinical and experimental immunology · 2012Article
- Sources of Urinary Proteins and their Analysis by Urinary Proteomics for the Detection of Biomarkers of Disease.Proteomics. Clinical applications · 2009Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
IgA nephropathy is the most common primary glomerulonephritis and is a frequent cause for chronic kidney disease in children and young adults. Glomerular deposition of IgA also characterizes other renal disorders, including Henoch-Schoenlein purpura nephritis and immune-complex glomerulonephritis afflicting patients with liver disease due to chronic infection with the hepatitis C virus. Several treatment options are often considered, with the goal to prevent end-stage renal failure. Unfortunately, the diagnosis currently requires an invasive procedure, a renal biopsy. Because of the inherent risks, repetitive renal biopsy is frequently foregone as a means to monitor the clinical course or response to treatment. Recent advances in the analysis of the urinary proteome suggest that the excreted polypeptides include disease-specific patterns. We review recent studies of the various techniques for the identification and validation of such urinary biomarkers of IgA-associated glomerulonephritides. Currently, capillary electrophoresis coupled with mass spectrometry (MS) offers the greatest promise. To date, it seems more likely that disease-specific urinary polypeptide biomarkers are comprised of a panel of several distinct and well-defined peptides rather than a single molecule. Even most patients in clinical remission with normal clinical testing (dipstick urinalysis and quantitative proteinuria) were correctly classified by the pattern of polypeptides identified by capillary electrophoresis coupled with MS. With confirmation and refinement, such urinary testing may provide a tool for the diagnosis and monitoring of patients with IgA-associated renal diseases that is more sensitive than current standard clinical testing and far less risky than renal biopsy.
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