ArticleJournal of neuro-oncology2008
Supratentorial primitive neuroectodermal tumors: a Canadian pediatric brain tumor consortium report.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
- Outcome and prognostic factors for children with supratentorial primitive neuroectodermal tumors treated with carboplatin during radiotherapy: a report from the Children's Oncology Group.Pediatric blood & cancer · 2015Trial
- Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006.Journal of neuro-oncology · 2011Trial
- C19MC amplification and expression of Lin28A and Olig2 in the classification of embryonal tumors of the central nervous system: A 14-year retrospective study from a tertiary care center.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database.PloS one · 2019Observational
- Molecular Classification and Management of Rare Pediatric Embryonal Brain Tumors.Current oncology reports · 2018Review
- The incidence of brainstem primitive neuroectodermal tumors of childhood based on SEER data.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Management and outcome of children and adolescents with non-medulloblastoma CNS embryonal tumors in Spain: room for improvement in standards of care.Journal of neuro-oncology · 2018Article
- Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival.Case reports in surgery · 2018Article
- Article
- First report of tumor treating fields use in combination with bevacizumab in a pediatric patient: a case report.CNS oncology · 2017Article
- Long-term safety of growth hormone replacement therapy after childhood medulloblastoma and PNET: it is time to set aside old concerns.Journal of neuro-oncology · 2017Article
- p53 Restoration in Induction and Maintenance of Senescence: Differential Effects in Premalignant and Malignant Tumor Cells.Molecular and cellular biology · 2016Article
- Treatment Outcome and Prognostic Molecular Markers of Supratentorial Primitive Neuroectodermal Tumors.PloS one · 2016Article
- Pediatric Primitive Neuroectodermal Tumors of the Central Nervous System Differentially Express Granzyme Inhibitors.PloS one · 2016Article
- Treatment outcome and patterns of failure in patients of pinealoblastoma: review of literature and clinical experience from a regional cancer centre in north India.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
- Clinical outcomes of children and adults with central nervous system primitive neuroectodermal tumor.Journal of neuro-oncology · 2014Article
- Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant.Journal of neuro-oncology · 2014Article
- MYCN amplification predicts poor outcome for patients with supratentorial primitive neuroectodermal tumors of the central nervous system .Neuro-oncology · 2014Article
- A patient tumor-derived orthotopic xenograft mouse model replicating the group 3 supratentorial primitive neuroectodermal tumor in children.Neuro-oncology · 2014Article
- Survival analysis for apparent diffusion coefficient measures in children with embryonal brain tumours.Neuro-oncology · 2012Article
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSupratentorial primitive neuroectodermal tumors (SPNET) are rare tumors accounting for only 2.5% of childhood brain tumors. The purpose of this study was to describe the range of treatment regimens used to treat pediatric SPNET in Canada and to identify prognostic factors for overall survival in this population.
methodsThis study was a retrospective clinical analysis of SPNET patients treated over the last 10 years in Canada. A questionnaire was developed and distributed to all institutions in Canada who treat pediatric patients. Data were collected for patients <19 years of age who were diagnosed and treated for SPNET between 1995 and 2005.
resultsData were obtained for 48 eligible patients. The stages of patients for whom complete data were provided were 80, 3, and 16% for metastatic stage M0, M1, and M2/3, respectively. The best responses to therapy included complete response in 44%, partial response in 8%, still on therapy in 2%, progressive disease in 31%, toxic death in 2%, and no therapy given in 12%. The 4-year survival was 37.7 +/- 7.6%. The factors associated with an increase in survival were the use of radiation therapy and chemotherapy, and age >2 years. Overall survival was not affected by metastatic disease at diagnosis, tumor site, or degree of initial resection.
conclusionsSurvival is poor in SPNET patients but highest in those who received chemotherapy and radiation therapy. Further studies are needed to improve the survival of these patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.