ArticleEuropean journal of nuclear medicine and molecular imaging2007
Quantification of myocardial blood flow with 82Rb dynamic PET imaging.
Article in European journal of nuclear medicine and molecular imaging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers.
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Who cites it
208 citing papers in PubMed.
- Heart Rate Variability Biofeedback and Mental Stress Myocardial Flow Reserve: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Effect of a single ultra processed meal on myocardial endothelial function, adenosine mediated effects and cognitive performances.Scientific reports · 2025Trial
- Added value of myocardial blood flow usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Trial
- Effects of Empagliflozin on Myocardial Flow Reserve in Patients With Type 2 Diabetes Mellitus: The SIMPLE Trial.Journal of the American Heart Association · 2021Trial
- Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Trial
- Coronary flow velocity reserve by echocardiography: feasibility, reproducibility and agreement with PET in overweight and obese patients with stable and revascularized coronary artery disease.Cardiovascular ultrasound · 2016Trial
- Feasibility and operator variability of myocardial blood flow and reserve measurements with ⁹⁹mTc-sestamibi quantitative dynamic SPECT/CT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2014Trial
- Phase II safety and clinical comparison with single-photon emission computed tomography myocardial perfusion imaging for detection of coronary artery disease: flurpiridaz F 18 positron emission tomography.Journal of the American College of Cardiology · 2013Trial
- Quantification of myocardial blood flow with 82Rb positron emission tomography: clinical validation with 15O-water.European journal of nuclear medicine and molecular imaging · 2012Trial
- Association of rheumatoid arthritis with major adverse cardiovascular events despite normal myocardial perfusion imaging.American journal of preventive cardiology · 2026Article
- Patlak-Guided Self-Supervised Learning for Dynamic PET Denoising.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Establishing normal myocardial blood flow and myocardial flow reserve values: a rubidium-82 positron emission tomography study.European journal of nuclear medicine and molecular imaging · 2026Article
- Paradoxical ST-segment depression at high blood flow in ANOCA: a hypothesis-generating analysis.The international journal of cardiovascular imaging · 2026Article
- Comparison of deep learning and particle smoother EM methods for estimation of Rb-82 myocardial perfusion PET kinetic parameters.Medical physics · 2026Article
- Deep Image Prior-Incorporated Direct PET Parametric Image Reconstruction.IEEE transactions on medical imaging · 2026Article
- Fully automatic left ventricle segmentation in [Formula: see text]Rb PET/CT Using a semi-supervised nnU-net.EJNMMI research · 2026Article
- Coronary microvascular dysfunction in systemic sclerosis: insights from PET-derived myocardial flow reserve.Rheumatology (Oxford, England) · 2026Article
- D-SPECT combined with deep learning predicts obstructive coronary artery disease.Frontiers in cardiovascular medicine · 2026Article
- A foundation transformer model with self-supervised learning for ECG-based assessment of cardiac and coronary function.NEJM AI · 2025Article
- The impact of fast vs. slow rubidium-82 infusion profile on precision and accuracy of PET myocardial blood flow perfusion metrics using a 1-tissue compartment model.European heart journal. Imaging methods and practice · 2025Article
148 more citing papers are in PubMed but not listed here.
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6 authors.
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Abstract
purposeThe PET tracer (82)Rb is commonly used to evaluate regional perfusion defects for the diagnosis of coronary artery disease. There is limited information on the quantification of myocardial blood flow and flow reserve with this tracer. The goal of this study was to investigate the use of a one-compartment model of (82)Rb kinetics for the quantification of myocardial blood flow.
methodsFourteen healthy volunteers underwent rest and dipyridamole stress imaging with both (13)N-ammonia and (82)Rb within a 2-week interval. Myocardial blood flow was estimated from the time-activity curves measured with (13)N-ammonia using a standard two-compartment model. The uptake parameter of the one-compartment model was estimated from the time-activity curves measured with (82)Rb. To describe the relationship between myocardial blood flow and the uptake parameter, a nonlinear extraction function was fitted to the data. This function was then used to convert estimates of the uptake parameter to flow estimates. The extraction function was validated with an independent data set obtained from 13 subjects with documented evidence of coronary artery disease (CAD).
resultsThe one-compartment model described (82)Rb kinetics very well (median R-square = 0.98). The flow estimates obtained with (82)Rb were well correlated with those obtained with (13)N-ammonia (r = 0.85), and the best-fit line did not differ significantly from the identity line. Data obtained from the subjects with CAD confirmed the validity of the estimated extraction function.
conclusionIt is possible to obtain accurate estimates of myocardial blood flow and flow reserve with a one-compartment model of (82)Rb kinetics and a nonlinear extraction function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.