ArticleNeurochemical research2008
Intense exercise induces mitochondrial dysfunction in mice brain.
Article in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Effectiveness of supplementation with date seed (Phoenix dactylifera) as a functional food on inflammatory markers, muscle damage, and BDNF following high-intensity interval training: a randomized, double-blind, placebo-controlled trial.European journal of nutrition · 2023Trial
- Exercise, fitness, and neurocognitive function in older adults: the "selective improvement" and "cardiovascular fitness" hypotheses.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2008Trial
- Effects of Treadmill Exercise on Social Behavior in Rats Exposed to Thimerosal with Respect to the Hippocampal Level of GluN1, GluN2A, and GluN2B.Journal of molecular neuroscience : MN · 2022Article
- Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats.International journal of environmental research and public health · 2021Article
- Synergistic effects of quercetin and regular exercise on the recovery of spatial memory and reduction of parameters of oxidative stress in animal model of Alzheimer's disease.EXCLI journal · 2020Article
- Peripheral blood metabolome predicts mood change-related activity in mouse model of bipolar disorder.Molecular brain · 2019Article
- The effects of moderate exercise and overtraining on learning and memory, hippocampal inflammatory cytokine levels, and brain oxidative stress markers in rats.The journal of physiological sciences : JPS · 2019Article
- Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence.Neurochemical research · 2019Article
- Benefit effect of REM-sleep deprivation on memory impairment induced by intensive exercise in male wistar rats: with respect to hippocampal BDNF and TrkB.Nature and science of sleep · 2019Article
- Filling the void: a role for exercise-induced BDNF and brain amyloid precursor protein processing.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Review
- Neuroprotective Effects of Exercise Treatments After Injury: The Dual Role of Neurotrophic Factors.Current neuropharmacology · 2017Review
- Effects of Regular Treadmill Exercise on a DNA Oxidative-Damage Marker and Total Antioxidant Capacity in Rat Hippocampal Tissue.Journal of clinical neurology (Seoul, Korea) · 2016Article
- Can Exercise Make You Smarter, Happier, and Have More Neurons? A Hormetic Perspective.Frontiers in neuroscience · 2016Article
- The dose-dependent antioxidant effects of physical exercise in the hippocampus of mice.Neurochemical research · 2014Article
- Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone Guidance.Journal of ocular biology · 2013Article
- Effect of exercise on mouse liver and brain bioenergetic infrastructures.Experimental physiology · 2013Article
- Mitochondrial dynamics regulate growth cone motility, guidance, and neurite growth rate in perinatal retinal ganglion cells in vitro.Investigative ophthalmology & visual science · 2012Article
- Cigarette smoke inhibits brain mitochondrial adaptations of exercised mice.Neurochemical research · 2011Article
- Aerobic exercise alters analgesia and neurotrophin-3 synthesis in an animal model of chronic widespread pain.Physical therapy · 2010Article
- Physical exercise increases mitochondrial function and reduces oxidative damage in skeletal muscle.European journal of applied physiology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are conflicts between the effects of free radical over-production induced by exercise on neurotrophins and brain oxidative metabolism. The objective of this study was to investigate the effects of intense physical training on brain-derived neurotrophic factor (BDNF) levels, COX activity, and lipoperoxidation levels in mice brain cortex. Twenty-seven adult male CF1 mice were assigned to three groups: control untrained, intermittent treadmill exercise (3 x 15 min/day) and continuous treadmill exercise (45 min/day). Training significantly (P < 0.05) increased citrate synthase activity when compared to untrained control. Blood lactate levels classified the exercise as high intensity. The intermittent training significantly (P < 0.05) reduced in 6.5% the brain cortex COX activity when compared to the control group. BDNF levels significantly (P < 0.05) decreased in both exercise groups. Besides, continuous and intermittent exercise groups significantly (P < 0.05) increased thiobarbituric acid reactive species levels in the brain cortex. In summary, intense exercise promoted brain mitochondrial dysfunction due to decreased BDNF levels in the frontal cortex of mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.