ArticleCellular and molecular neurobiology2007
Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients.
Article in Cellular and molecular neurobiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- FMolecular biology reports · 2023Pooled it
- Nutritional and Biochemical Parameters Among Multiple Sclerosis Patients: A Case-Control Study.Cureus · 2021Article
- ZIKV infection regulates inflammasomes pathway for replication in monocytes.Scientific reports · 2017Article
- The Dual Function of Reactive Oxygen/Nitrogen Species in Bioenergetics and Cell Death: The Role of ATP Synthase.Oxidative medicine and cellular longevity · 2016Review
- The POLG Polyglutamine Tract Variants in Iranian Patients with Multiple Sclerosis.Iranian journal of child neurology · 2015Article
- Article
- Stressed cybrids model demyelinated axons in multiple sclerosis.Metabolic brain disease · 2013Article
- Investigation of the Mitochondrial ATPase 6/8 and tRNA(Lys) Genes Mutations in Autism.Cell journal · 2012Article
- Is 8860 variation a rare polymorphism or associated as a secondary effect in HCM disease?Archives of medical science : AMS · 2011Article
- Effects of phytoestrogen on mitochondrial structure and function of hippocampal CA1 region of ovariectomized rats.Cellular and molecular neurobiology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As with chromosomal DNA, the mitochondrial DNA (mtDNA) can contain mutations that are highly pathogenic . In fact, many diseases of the central nervous system are known to be caused by mutations in mtDNA. Dysfunction of the mitochondrial Respiratory Chain (RC) has been shown in patients with neurological disease including Alzheimer's disease (AD), Parkinson's disease (PD) and Multiple sclerosis (MS). MS is a demyelinating disease of central nervous system characterized by morphological hallmarks of inflammation, demyelination and axonal loss. Considering this importance, we decided to investigate several highly mutative parts of mtDNA for point mutations as MT-LTI (tRNA(Leucine1(UUA/G))), MT-NDI (NADH Dehydrogenase subunit 1), MT-COII (Cytochrome c oxidase subunit II), MT-TK (tRNA(Lysine)), MT-ATP8 (ATP synthase subunit F0 8) and MT-ATP6 (ATP synthase subunit F0 6) in 20 Iranian MS patients and 80 age-matched control subjects by PCR and automated DNA sequencing to evaluate any probable point mutations. Our results revealed that 15 (75%) out of 20 MS patients had point mutations. Some of point mutations were newly found in this study. This study suggested that point mutation occurred in mtDNA might be involved in pathogenesis of MS.
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