ArticleDNA repair2007
Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.
Article in DNA repair, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins.Molecular and cellular biology · 2016Article
- Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication.PLoS genetics · 2015Article
- Article
- Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening.Frontiers in oncology · 2013Article
- Genome-wide screen reveals replication pathway for quasi-palindrome fragility dependent on homologous recombination.PLoS genetics · 2013Article
- Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Molecular and cellular biology · 2012Article
- Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells.Molecular cell · 2012Article
- Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast.Molecular and cellular biology · 2011Article
- Polymerase epsilon is required to maintain replicative senescence.Molecular and cellular biology · 2011Article
- Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping.The EMBO journal · 2010Article
- A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe.Cell division · 2010Article
- Article
- Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping.DNA repair · 2009Article
- Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint.Molecular cell · 2008Article
- Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response.The EMBO journal · 2008Article
- High rates of "unselected" aneuploidy and chromosome rearrangements in tel1 mec1 haploid yeast strains.Genetics · 2008Article
- DNA damage response at functional and dysfunctional telomeres.Genes & development · 2008Review
- Molecular mechanisms involved in initiation of the DNA damage response.Molecular & cellular oncologyReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Mrc1 (Mediator of Replication Checkpoint 1) is a component of the DNA replication fork machinery and is necessary for checkpoint activation after replication stress. In this study, we addressed the role of Mrc1 at uncapped telomeres. Our experiments show that Mrc1 contributes to the vitality of both cdc13-1 and yku70Delta telomere capping mutants. Cells with telomere capping defects containing MRC1 or mrc1(AQ), a checkpoint defective allele, exhibit similar growth, suggesting growth defects of cdc13-1 mrc1Delta are not due to checkpoint defects. This is in accordance with Mrc1-independent Rad53 activation after telomere uncapping. Poor growth of cdc13-1 mutants in the absence of Mrc1 is a result of enhanced single stranded DNA accumulation at uncapped telomeres. Consistent with this, deletion of EXO1, encoding a nuclease that contributes to single stranded DNA accumulation after telomere uncapping, improves growth of cdc13-1 mrc1Delta strains and decreases ssDNA production. Our observations show that Mrc1, a core component of the replication fork, plays an important role in telomere capping, protecting from nucleases and checkpoint pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.