ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2007
Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Genetic association between IL23R rs11209026 and rs10889677 polymorphisms and risk of Crohn's disease and ulcerative colitis: evidence from 41 studies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Pooled it
- Association of Interleukin-23 receptor gene polymorphisms with susceptibility to Crohn's disease: A meta-analysis.Scientific reports · 2015Pooled it
- Interleukin-23 receptor genetic polymorphisms and Crohn's disease susceptibility: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Pooled it
- Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2010Pooled it
- Immune response to influenza A/H1N1 vaccine in inflammatory bowel disease patients treated with anti TNF-α agents: effects of combined therapy with immunosuppressants.Journal of Crohn's & colitis · 2013Trial
- Immune response to influenza vaccine in children with inflammatory bowel disease.The American journal of gastroenterology · 2009Trial
- Diagnosis and management of inflammatory bowel disease in children.BMJ (Clinical research ed.) · 2017Review
- Immunizations in children with inflammatory bowel disease treated with immunosuppressive therapy.Gastroenterology & hepatology · 2014Article
- The impact of genomics on pediatric research and medicine.Pediatrics · 2012Review
- Role of genetics in the diagnosis and prognosis of Crohn's disease.World journal of gastroenterology · 2012Review
- Role of genetics in the diagnosis and prognosis of Crohn's disease.World journal of gastroenterology · 2011Review
- Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens.Inflammatory bowel diseases · 2011Article
- Polymorphisms of IL23R and Fuchs' syndrome in a Chinese Han population.Molecular vision · 2010Article
- IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population.Gastroenterology research and practice · 2010Article
- Genome-wide association studies--a summary for the clinical gastroenterologist.World journal of gastroenterology · 2009Article
- Immunizations in patients with inflammatory bowel disease.Inflammatory bowel diseases · 2009Review
- Contribution of rs11465788 in IL23R gene to Crohn's disease susceptibility and phenotype in Chinese population.Journal of genetics · 2009Article
- Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats.World journal of gastroenterology · 2009Article
- IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.BMC medical genetics · 2009Article
- Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.Nature genetics · 2008Article
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Authors and funding
20 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsRecently an association was shown between the single nucleotide polymorphism (SNP), rs11209026, within the interleukin-23 receptor (IL23R) locus and Crohn's disease (CD) as a consequence of a genome-wide association study of this disease in adults. We examined the effects of this and other previously reported SNPs at this locus with respect to CD in children.
methodsBy using data from our ongoing genome-wide association study in our cohort of 142 pediatric CD patients and 281 matched controls, we investigated the association of the previously reported SNPs at the IL23R locus with the childhood form of this disease.
resultsBy using the Fisher exact test, the minor allele frequency of rs11209026 in the patients was 1.75%, whereas it was 6.61% in the controls, yielding a protective odds ratio (OR) of 0.25 (95% confidence interval, 0.10-0.65; 1-sided P = 9.2 x 10(-4)). Furthermore, of all the SNPs previously reported, rs11209026 was associated the most strongly. A subsequent family based association test (which is more resistant to population stratification) with 65 sets of trios derived from our initial patient cohort yielded significant association with rs11209026 in a transmission disequilibrium test (1-sided P = .0017). In contrast, no association was detected to the caspase-recruitment domain 15 gene for the inflammatory bowel disease phenotype.
conclusionsThe OR of the IL23R variant in our pediatric study is highly comparable with that reported previously in a non-Jewish adult inflammatory bowel disease case-control cohort (OR, 0.26). As such, variants in the IL23R gene confer a similar magnitude of risk of CD to children as for their adult counterparts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.