ArticleDevelopmental biology2007
Mutations in the Drosophila alphaPS2 integrin subunit uncover new features of adhesion site assembly.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix.Open biology · 2019Article
- Integrin signaling downregulates filopodia during muscle-tendon attachment.Journal of cell science · 2018Article
- A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation.Current biology : CB · 2017Article
- In vivo quantitative analysis of Talin turnover in response to force.Molecular biology of the cell · 2015Article
- The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering.PLoS genetics · 2014Article
- Two protein N-acetylgalactosaminyl transferases regulate synaptic plasticity by activity-dependent regulation of integrin signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development.Current opinion in cell biology · 2012Review
- Parvin-ILK: An intimate relationship.Bioarchitecture · 2012Article
- Extracellular matrix in development: insights from mechanisms conserved between invertebrates and vertebrates.Cold Spring Harbor perspectives in biology · 2011Review
- A central multifunctional role of integrin-linked kinase at muscle attachment sites.Journal of cell science · 2011Article
- An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligand.The Journal of biological chemistry · 2010Article
- Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis.Development (Cambridge, England) · 2009Article
- RacGAP50C directs perinuclear gamma-tubulin localization to organize the uniform microtubule array required for Drosophila myotube extension.Development (Cambridge, England) · 2009Article
- Differences in regulation of Drosophila and vertebrate integrin affinity by talin.Molecular biology of the cell · 2008Article
- Zasp is required for the assembly of functional integrin adhesion sites.The Journal of cell biology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The Drosophila alphaPS2betaPS integrin is required for diverse development events, including muscle attachment. We characterized six unusual mutations in the alphaPS2 gene that cause a subset of the null phenotype. One mutation changes a residue in alphaPS2 that is equivalent to the residue in alphaV that contacts the arginine of RGD. This change severely reduced alphaPS2betaPS affinity for soluble ligand, abolished the ability of the integrin to recruit laminin to muscle attachment sites in the embryo and caused detachment of integrins and talin from the ECM. Three mutations that alter different parts of the alphaPS2 beta-propeller, plus a fourth that eliminated a late phase of alphaPS2 expression, all led to a strong decrease in alphaPS2betaPS at muscle ends, but, surprisingly, normal levels of talin were recruited. Thus, although talin recruitment requires alphaPS2betaPS, talin levels are not simply specified by the amount of integrin at the adhesive junction. These mutations caused detachment of talin and actin from integrins, suggesting that the integrin-talin link is weaker than the ECM-integrin link.
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