ArticleBritish journal of pharmacology2007
Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice.
Article in British journal of pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
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- Pharmacological effects of higenamine based on signalling pathways and mechanism of action.Frontiers in pharmacology · 2022Review
- Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing.eLife · 2021Article
- Higenamine exerts an antispasmodic effect on cold-induced vasoconstriction by regulating the PI3K/Akt, ROS/α2C-AR and PTK9 pathways independently of the AMPK/eNOS/NO axis.Experimental and therapeutic medicine · 2019Article
- Vascular responses of the extremities to transdermal application of vasoactive agents in Caucasian and African descent individuals.European journal of applied physiology · 2015Article
- A vascular mechanistic approach to understanding Raynaud phenomenon.Nature reviews. Rheumatology · 2015Review
- TRPA1 is essential for the vascular response to environmental cold exposure.Nature communications · 2014Article
- Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice.BMC veterinary research · 2013Article
- Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2.American journal of physiology. Cell physiology · 2013Article
- A general linear model-based approach for inferring selection to climate.BMC genetics · 2013Article
- Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.American journal of physiology. Cell physiology · 2012Article
- Intracellular α(2C)-adrenoceptors: storage depot, stunted development or signaling domain?Biochimica et biophysica acta · 2011Review
- Aging and the control of human skin blood flow.Frontiers in bioscience (Landmark edition) · 2010Article
- Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors.American journal of physiology. Heart and circulatory physiology · 2008Article
- Altered mechanisms of thermoregulatory vasoconstriction in aged human skin.Exercise and sport sciences reviews · 2008Article
- Regulation of vascular reactivity in scleroderma: new insights into Raynaud's phenomenon.Rheumatic diseases clinics of North America · 2008Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe reduction of skin blood flow induced by local cooling results from a reflex increase in sympathetic output and an enhanced vasoconstrictor activity of cutaneous vessels. The present study investigated the latter local response in vivo in tetrodotoxin-treated mice, in which the sympathetic nerve tone was abolished. EXPERIMENTAL APPROACH: Male ddY mice, anaesthetized with pentobarbitone, were treated with tetrodotoxin and artificially ventilated. The plantar skin blood flow (PSBF) was measured by laser Doppler flowmetry. KEY
resultsCooling the air temperature around the left foot from 25 to 10 degrees C decreased the PSBF of the left foot. Bunazosin, an alpha (1)-adrenoceptor antagonist, RS79948, an alpha (2)-adrenoceptor antagonist, and MK-912, an alpha (2C)-adrenoceptor antagonist, all significantly inhibited the cooling-induced reduction of PSBF; the inhibition by bunazosin was relatively small compared with that by RS79948 and MK-912. The response was not affected by guanethidine or bretylium, but was diminished in adrenalectomized mice. An intra-arterial injection of clonidine, an alpha (2)-adrenoceptor agonist, to the left iliac artery of adrenalectomized mice caused a transient decrease in PSBF, which was significantly augmented at 10 degrees C. MK-912 suppressed only the augmented portion at 10 degrees C. Y-27632, H-1152 and fasudil, Rho kinase inhibitors, also inhibited the cooling-induced reduction of PSBF. RS79948 caused no further reduction of the cooling-induced response after the inhibition by Y-27632. CONCLUSIONS AND IMPLICATIONS: Local cooling-induced reduction of skin blood flow in mice primarily results from increased reactivity of alpha (2C)-adrenoceptors to circulating catecholamines, in which the Rho/Rho kinase pathway is involved.
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