ArticleThe Journal of nutritional biochemistry2008
The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects.
Article in The Journal of nutritional biochemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars.Diabetes care · 2020Trial
- Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial.BMJ (Clinical research ed.) · 2018Trial
- Effects of Dietary Sweet Potato Tuber Meal on Production Performance, Meat Quality and Intestine of Wenchang Chickens.Biology · 2026Article
- Genome wide transcriptome analysis provides bases on hepatic lipid metabolism disorder affected by increased dietary grain ratio in fattening lambs.BMC genomics · 2023Article
- Effect of Dietary Linoleic Acid (18:2n-6) Supplementation on the Growth Performance, Fatty Acid Profile, and Lipid Metabolism Enzyme Activities of Coho Salmon (Animals : an open access journal from MDPI · 2022Article
- Circulating omega-7 fatty acids are differentially related to metabolic dysfunction and incident type II diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA).Diabetes & metabolism · 2020Article
- Bromocriptine mesylate improves glucose tolerance and disposal in a high-fat-fed canine model.American journal of physiology. Endocrinology and metabolism · 2020Article
- Serial Biomarkers of De Novo Lipogenesis Fatty Acids and Incident Heart Failure in Older Adults: The Cardiovascular Health Study.Journal of the American Heart Association · 2020Article
- Article
- Downregulation of de Novo Fatty Acid Synthesis in Subcutaneous Adipose Tissue of Moderately Obese Women.International journal of molecular sciences · 2015Article
- The role for adipose tissue in weight regain after weight loss.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Review
- Association of high carbohydrate versus high fat diet with glycated hemoglobin in high calorie consuming type 2 diabetics.Journal of diabetes and metabolic disorders · 2013Article
- De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health.Nature communications · 2013Article
- Trans-palmitoleic acid, metabolic risk factors, and new-onset diabetes in U.S. adults: a cohort study.Annals of internal medicine · 2010Article
- Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.The American journal of clinical nutrition · 2010Article
- Macronutrient intakes and cardio metabolic risk factors in high BMI African American children.Nutrition & metabolism · 2009Article
- Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.Diabetologia · 2009Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHepatic de novo lipogenesis (DNL) is markedly stimulated in humans by low-fat diets enriched in simple sugars. However, the dietary responsiveness of the key enzyme controlling DNL in human adipose tissue, fatty acid synthase (FAS), is uncertain. HYPOTHESIS: Adipose tissue mRNA for FAS is increased in lean and obese subjects when hepatic DNL is elevated by a eucaloric, low-fat, high-sugar diet.
designTwelve lean and seven obese volunteers were given two eucaloric diets (10% vs. 30% fat; 75% vs. 55% carbohydrate; sugar/starch 60/40) each for 2 weeks by a random-order cross-over design. FAS mRNA in abdominal and gluteal adipose tissues was compared to hepatic DNL measured in serum by isotopic and nonisotopic methods. Adipose tissue mRNA for tumor necrosis factor-alpha and IL-6, which are inflammatory cytokines that modulate DNL, was also assayed.
resultsThe low-fat high-sugar diet induced a 4-fold increase in maximum hepatic DNL (P<.001) but only a 1.3-fold increase in adipose tissue FAS mRNA (P=.029) and no change in cytokine mRNA. There was a borderline significant positive correlation between changes in FAS mRNA and hepatic DNL (P=.039). Compared to lean subjects, obese subjects had lower levels of FAS mRNA and higher levels of cytokine mRNA (P<.001).
conclusionsThe results suggest that key elements of human adipose tissue DNL are less responsive to dietary carbohydrate than is hepatic DNL and may be regulated by diet-independent factors. Irrespective of diet, there is reduced expression of the FAS gene and increased expression of cytokine genes in adipose tissues of obese subjects.
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