ArticleVirology2007
Characterization of a small plaque variant of West Nile virus isolated in New York in 2000.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 33 citations in OpenAlex.
- Impact of climate change on the global circulation of chikungunya virus: current evidence, future projections, and adaptation strategies.Infectious diseases of poverty · 2026Review
- Review
- West Nile Virus (WNV): One-Health and Eco-Health Global Risks.Veterinary sciences · 2025Review
- West Nile virus unmasked: from gene variability to future challenges.Frontiers in cellular and infection microbiology · 2025Review
- Impact of climate change on the global circulation of West Nile virus and adaptation responses: a scoping review.Infectious diseases of poverty · 2024Article
- Insights into In Vitro Adaptation of EV71 and Analysis of Reduced Virulence by In Silico Predictions.Vaccines · 2023Article
- West Nile Virus Lineage 2 Spreads Westwards in Europe and Overwinters in North-Eastern Spain (2017-2020).Viruses · 2022Article
- Inhibition of Influenza Virus Replication by Oseltamivir Derivatives.Pathogens (Basel, Switzerland) · 2022Article
- Characterization of Plaque Variants and the Involvement of Quasi-Species in a Population of EV-A71.Viruses · 2020Article
- Article
- Impact of RNA Virus Evolution on Quasispecies Formation and Virulence.International journal of molecular sciences · 2019Review
- Association of spring-summer hydrology and meteorology with human West Nile virus infection in West Texas, USA, 2002-2016.Parasites & vectors · 2018Article
- Thermal experiments with the Asian bush mosquito (Aedes japonicus japonicus) (Diptera: Culicidae) and implications for its distribution in Germany.Parasites & vectors · 2018Article
- Transmission Dynamics of the West Nile Virus in Mosquito Vector Populations under the Influence of Weather Factors in the Danube Delta, Romania.EcoHealth · 2016Article
- Recovery of West Nile Virus Envelope Protein Domain III Chimeras with Altered Antigenicity and Mouse Virulence.Journal of virology · 2016Article
- Relating plaque morphology to respiratory syncytial virus subgroup, viral load, and disease severity in children.Pediatric research · 2015Article
- Climate change impacts on West Nile virus transmission in a global context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Environmental drivers of West Nile fever epidemiology in Europe and Western Asia--a review.International journal of environmental research and public health · 2013Review
- Nonconsensus West Nile virus genomes arising during mosquito infection suppress pathogenesis and modulate virus fitness in vivo.Journal of virology · 2011Article
- North American West Nile virus genotype isolates demonstrate differential replicative capacities in response to temperature.The Journal of general virology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
A small-plaque variant (SP) of West Nile virus (WNV) was isolated in Vero cell culture from kidney tissue of an American crow collected in New York in 2000. The in vitro growth of the SP and parental (WT) strains was characterized in mammalian (Vero), avian (DF-1 and PDE), and mosquito (C6/36) cells. The SP variant replicated less efficiently than did the WT in Vero cells. In avian cells, SP growth was severely restricted at high temperatures, suggesting that the variant is temperature sensitive. In mosquito cells, growth of SP and WT was similar, but in vivo in Culex pipiens (L.) there were substantial differences. Relative to WT, SP exhibited reduced replication following intrathoracic inoculation and lower infection, dissemination, and transmission rates following oral infection. Analysis of the full length sequence of the SP variant identified sequence differences which led to only two amino acid substitutions relative to WT, prM P54S and NS2A V61A.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.