ArticlePLoS pathogens2007
A challenge to the ancient origin of SIVagm based on African green monkey mitochondrial genomes.
Article in PLoS pathogens, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Host genetic and immune factors drive evasion of HIV-1 pathogenesis in viremic non-progressors.Med (New York, N.Y.) · 2025Article
- Article
- Contemporary Distribution, Estimated Age, and Prehistoric Migrations of Old World Monkey Retroviruses.Epidemiologia (Basel, Switzerland) · 2021Review
- CD4 receptor diversity in chimpanzees protects against SIV infection.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Recurrent Loss of APOBEC3H Activity during Primate Evolution.Journal of virology · 2018Article
- Endogenous retroviruses of non-avian/mammalian vertebrates illuminate diversity and deep history of retroviruses.PLoS pathogens · 2018Article
- Euphyllophyte Paleoviruses Illuminate Hidden Diversity and Macroevolutionary Mode of Caulimoviridae.Journal of virology · 2018Article
- Molecular characterization of a new mosaic Simian Immunodeficiency Virus in a naturally infected tantalus monkey (Chlorocebus tantalus) from Cameroon: a challenge to the virus-host co-evolution of SIVagm in African green monkeys.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- A primitive endogenous lentivirus in a colugo: insights into the early evolution of lentiviruses.Molecular biology and evolution · 2015Article
- The genome landscape of the african green monkey kidney-derived vero cell line.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Primate phylogenetic relationships and divergence dates inferred from complete mitochondrial genomes.Molecular phylogenetics and evolution · 2014Article
- New insights into an X-traordinary viral protein.Frontiers in microbiology · 2014Review
- Antagonism of SAMHD1 is actively maintained in natural infections of simian immunodeficiency virus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Host gene evolution traces the evolutionary history of ancient primate lentiviruses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Next-generation museomics disentangles one of the largest primate radiations.Systematic biology · 2013Article
- A simple model explains the dynamics of preferential host switching among mammal RNA viruses.Evolution; international journal of organic evolution · 2013Article
- Mitochondrial diversity and distribution of African green monkeys (chlorocebus gray, 1870).American journal of primatology · 2013Article
- SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations.PLoS pathogens · 2013Article
- Systems biology of the vervet monkey.ILAR journal · 2013Review
- Diversity and distribution of hantaviruses in South America.Journal of virology · 2012Article
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2 authors.
Funding
Abstract
While the circumstances surrounding the origin and spread of HIV are becoming clearer, the particulars of the origin of simian immunodeficiency virus (SIV) are still unknown. Specifically, the age of SIV, whether it is an ancient or recent infection, has not been resolved. Although many instances of cross-species transmission of SIV have been documented, the similarity between the African green monkey (AGM) and SIVagm phylogenies has long been held as suggestive of ancient codivergence between SIVs and their primate hosts. Here, we present well-resolved phylogenies based on full-length AGM mitochondrial genomes and seven previously published SIVagm genomes; these allowed us to perform the first rigorous phylogenetic test to our knowledge of the hypothesis that SIVagm codiverged with the AGMs. Using the Shimodaira-Hasegawa test, we show that the AGM mitochondrial genomes and SIVagm did not evolve along the same topology. Furthermore, we demonstrate that the SIVagm topology can be explained by a pattern of west-to-east transmission of the virus across existing AGM geographic ranges. Using a relaxed molecular clock, we also provide a date for the most recent common ancestor of the AGMs at approximately 3 million years ago. This study substantially weakens the theory of ancient SIV infection followed by codivergence with its primate hosts.
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