ArticleJournal of clinical microbiology1991
Rapid clearance of Candida albicans mannan antigens by liver and spleen in contrast to prolonged circulation of Cryptococcus neoformans antigens.
Article in Journal of clinical microbiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Biology and function of exo-polysaccharides from human fungal pathogens.Current clinical microbiology reports · 2020Article
- Disseminated Invasive Candidiasis in an Immunocompetent Host.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2019Article
- Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure.Clinical and experimental immunology · 2019Article
- Biodistribution and scintigraphic evaluation of 99mTc-Mannan complex.Discoveries (Craiova, Romania) · 2016Article
- Increased sensitivity of mannanemia detection tests by joint detection of alpha- and beta-linked oligomannosides during experimental and human systemic candidiasis.Journal of clinical microbiology · 2004Article
- Cross-reactivity of the PLATELIA CANDIDA antigen detection enzyme immunoassay with fungal antigen extracts.Journal of clinical microbiology · 2003Article
- New enzyme immunoassays for sensitive detection of circulating Candida albicans mannan and antimannan antibodies: useful combined test for diagnosis of systemic candidiasis.Journal of clinical microbiology · 1999Article
- Clearances of Candida albicans-derived alpha- and beta-linked mannose residues in sera from patients with candidiasis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Article
- Intravenous injection of Candida-derived mannan results in elevated tumor necrosis factor alpha levels in serum.Infection and immunity · 1996Article
- Tissue localization of Cryptococcus neoformans glucuronoxylomannan in the presence and absence of specific antibody.Infection and immunity · 1995Article
- D-arabinitol versus mannan antigen and candidal protein antigen as a serum marker for Candida pyelonephritis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1995Article
- New cause for false-positive results with the Pastorex Aspergillus antigen latex agglutination test.Journal of clinical microbiology · 1993Article
- Diagnosis of invasive mycoses in severely immunosuppressed patients.Annals of hematology · 1993Review
- Diagnostic value of determination of serum mannan concentrations in patients with candiduria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1993Article
- Retrospective evaluation of two latex agglutination tests for detection of circulating antigens during invasive candidosis.Journal of clinical microbiology · 1992Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clearances of mannan antigen from Candida albicans and glucuronoxylomannan antigen from Cryptococcus neoformans were examined in nonimmune rabbits by using self-prepared latex agglutination tests. Injected intravenously, 20 mg of Candida mannan antigen was cleared from the serum with a half-life of approximately 2 h. In contrast, 20 micrograms of Cryptococcus glucuronoxylomannan antigen had a half-life in serum of approximately 24 h. At the latest, 9 h after injection, both antigens were no longer detectable without pretreatment of serum samples with protease and heating to 100 degrees C, thus indicating rapid binding by serum proteins other than immunoglobulins. Candida mannan antigen clearance was also examined in nonimmune mice after intravenous injection of (i) 200 micrograms of Candida mannan antigen, which accumulated in the liver and spleen and persisted for 97 days; (ii) 2 x 10(7) ethanol-killed Candida blastospores, which was accompanied by rapid clearance of mannan from the blood but accumulation of mannan in the liver and spleen and slow clearance from these organs; (iii) 6 x 10(6) viable C. albicans cells (lethal infection), which resulted in a rapid decrease of Candida CFU in the blood, liver, and spleen during the first 8 h, after which blood cultures were negative on day 2 and viable Candida burdens in the liver and spleen persisted at 10(5) CFU/g, whereas Candida mannan antigen continued to circulate in the bloodstream and accumulated in the liver and spleen.
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