ArticleThe American journal of clinical nutrition2007
Independent associations of insulin resistance with high whole-body intermuscular and low leg subcutaneous adipose tissue distribution in obese HIV-infected women.
Article in The American journal of clinical nutrition, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 35 citations in OpenAlex.
- Adipose Tissue Redistribution and Ectopic Lipid Deposition in Active Acromegaly and Effects of Surgical Treatment.The Journal of clinical endocrinology and metabolism · 2015Trial
- Intramuscular adipose tissue: from progenitor to pathology.American journal of physiology. Cell physiology · 2025Review
- Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling.Molecular aspects of medicine · 2024Review
- Secondary diabetes mellitus in acromegaly.Endocrine · 2023Review
- Long-term Outcome of Body Composition, Ectopic Lipid, and Insulin Resistance Changes With Surgical Treatment of Acromegaly.Journal of the Endocrine Society · 2023Article
- The acromegaly lipodystrophy.Frontiers in endocrinology · 2022Article
- Body Composition Changes with Long-term Pegvisomant Therapy of Acromegaly.Journal of the Endocrine Society · 2021Article
- A novel method for the quantification of fatty infiltration in skeletal muscle.Skeletal muscle · 2017Article
- Review
- Serum glycine is associated with regional body fat and insulin resistance in functionally-limited older adults.PloS one · 2013Article
- Insulin sensitivity is associated with thigh adipose tissue distribution in healthy postmenopausal women.Metabolism: clinical and experimental · 2012Article
- Rare adipose disorders (RADs) masquerading as obesity.Acta pharmacologica Sinica · 2012Review
- Management of fat accumulation in patients with HIV infection.Current HIV/AIDS reports · 2011Review
- Developing an objective evaluation method to estimate diabetes risk in community-based settings.Diabetes technology & therapeutics · 2011Article
- Intermuscular adipose tissue and metabolic associations in HIV infection.Obesity (Silver Spring, Md.) · 2011Article
- Adipose tissue and volumetric bone mineral density of older Afro-Caribbean men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Longitudinal changes in regional fat content in HIV-infected children and adolescents.AIDS (London, England) · 2009Article
- Intermuscular and subcutaneous adipose tissue distributions differ in HIV+ versus HIV-men and women.International journal of body composition research · 2009Article
- Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly.The Journal of clinical endocrinology and metabolism · 2008Article
- Femoral-gluteal subcutaneous and intermuscular adipose tissues have independent and opposing relationships with CVD risk.Journal of applied physiology (Bethesda, Md. : 1985) · 2008Article
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8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity and insulin resistance are growing problems in HIV-positive (HIV+) women receiving highly active antiretroviral therapy (HAART).
objectiveThe objective was to determine the contribution of adipose tissue (AT) enlargement and distribution to the presence of insulin resistance in obese HIV+ women.
designWhole-body intermuscular AT (IMAT), visceral AT (VAT), subcutaneous AT (SAT), and SAT distribution (leg versus upper body) were measured by whole-body magnetic resonance imaging. Insulin sensitivity (S(I)) was measured with an intravenous glucose tolerance test in obese HIV+ women recruited because of their desire to lose weight (n=17) and in obese healthy controls (n=32).
resultsThe HIV+ women had relatively less whole-body SAT and more VAT and IMAT than did the controls (P<0.05 for all). A significant interaction by HIV status was observed for the relation of total SAT with S(I) (P<0.001 for the regression's slope interactions after adjustment for age, height, and weight). However, relations of IMAT, VAT, and SAT distribution (leg SAT as a percentage of total SAT; leg SAT%) with S(I) did not differ significantly between groups. For both groups combined, the best model predicting a low S(I) included significant contributions by both high IMAT and low leg SAT%, independent of age, height, and weight, and no interaction between groups was observed (overall r(2)=0.44, P=0.0003).
conclusionIn obese HIV+ women, high whole-body IMAT and low leg SAT% distribution are independently associated with insulin resistance.
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