ArticleMolecular biology of the cell2007
A novel pathway that coordinates mitotic exit with spindle position.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- The budding yeast GSK-3 homologue Mck1 is an essential component of the spindle position checkpoint.Open biology · 2022Article
- A novel role for the GTPase-activating protein Bud2 in the spindle position checkpoint.PloS one · 2012Article
- Fly meets yeast: checking the correct orientation of cell division.Trends in cell biology · 2011Review
- The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4.The Journal of cell biology · 2011Article
- Monitoring spindle orientation: Spindle position checkpoint in charge.Cell division · 2010Article
- The spindle position checkpoint is coordinated by the Elm1 kinase.The Journal of cell biology · 2010Article
- The spindle position checkpoint requires positional feedback from cytoplasmic microtubules.Current biology : CB · 2009Article
- Lte1 contributes to Bfa1 localization rather than stimulating nucleotide exchange by Tem1.The Journal of cell biology · 2009Article
- Interpreting spatial information and regulating mitosis in response to spindle orientation.Genes & development · 2009Article
- Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.Molecular biology of the cell · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In budding yeast, the spindle position checkpoint (SPC) delays mitotic exit until the mitotic spindle moves into the neck between the mother and bud. This checkpoint works by inhibiting the mitotic exit network (MEN), a signaling cascade initiated and controlled by Tem1, a small GTPase. Tem1 is regulated by a putative guanine exchange factor, Lte1, but the function and regulation of Lte1 remains poorly understood. Here, we identify novel components of the checkpoint that operate upstream of Lte1. We present genetic evidence in agreement with existing biochemical evidence for the molecular mechanism of a pathway that links microtubule-cortex interactions with Lte1 and mitotic exit. Each component of this pathway is required for the spindle position checkpoint to delay mitotic exit until the spindle is positioned correctly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.