ArticleJournal of neurophysiology2007
Muscarinic receptors control frequency tuning through the downregulation of an A-type potassium current.
Article in Journal of neurophysiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
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- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations.iScience · 2025Article
- Serotonergic Modulation of Sensory Neuron Activity and Behavior inFrontiers in integrative neuroscience · 2020Article
- Differences in Sodium Channel Densities in the Apical Dendrites of Pyramidal Cells of the Electrosensory Lateral Line Lobe.Frontiers in neural circuits · 2019Article
- Electrosensory neural responses to natural electro-communication stimuli are distributed along a continuum.PloS one · 2017Article
- Article
- Adaptation to second order stimulus features by electrosensory neurons causes ambiguity.Scientific reports · 2016Article
- Burst Firing in the Electrosensory System of Gymnotiform Weakly Electric Fish: Mechanisms and Functional Roles.Frontiers in computational neuroscience · 2016Review
- Mechanisms underlying the activity-dependent regulation of locomotor network performance by the Na+ pump.Scientific reports · 2015Article
- Electrosensory Midbrain Neurons Display Feature Invariant Responses to Natural Communication Stimuli.PLoS computational biology · 2015Article
- Serotonin modulates electrosensory processing and behavior via 5-HT2-like receptors.Neuroscience · 2014Article
- Neuromodulation of early electrosensory processing in gymnotiform weakly electric fish.The Journal of experimental biology · 2013Review
- Sub- and suprathreshold adaptation currents have opposite effects on frequency tuning.The Journal of physiology · 2012Article
- Diverse roles of G-protein coupled receptors in the regulation of neurohypophyseal hormone secretion.Journal of neuroendocrinology · 2012Review
- Efficient computation via sparse coding in electrosensory neural networks.Current opinion in neurobiology · 2011Review
- In vivo conditions influence the coding of stimulus features by bursts of action potentials.Journal of computational neuroscience · 2011Article
- Inhibition of SK and M channel-mediated currents by 5-HT enables parallel processing by bursts and isolated spikes.Journal of neurophysiology · 2011Article
- Neural heterogeneities and stimulus properties affect burst coding in vivo.Neuroscience · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The functional role of cholinergic input in the modulation of sensory responses was studied using a combination of in vivo and in vitro electrophysiology supplemented by mathematical modeling. The electrosensory system of weakly electric fish recognizes different environmental stimuli by their unique alteration of a self-generated electric field. Variations in the patterns of stimuli are primarily distinguished based on their frequency. Pyramidal neurons in the electrosensory lateral line lobe (ELL) are often tuned to respond to specific input frequencies. Alterations in the tuning of the pyramidal neurons may allow weakly electric fish to preferentially select for certain stimuli. Here we show that muscarinic receptor activation in vivo enhances the excitability, burst firing, and subsequently the response of pyramidal cells to naturalistic sensory input. Through a combination of in vitro electrophysiology and mathematical modeling, we reveal that this enhanced excitability and bursting likely results from the down-regulation of an A-type potassium current. Further, we provide an explanation of the mechanism by which these currents can mediate frequency tuning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.